阿司匹林联合氯吡格雷治疗大脑中动脉狭窄脑梗死的临床研究

Clinical research of aspirin combined with clopidogrel in the cerebral infarction of middle cerebral artery stenosis

目的分析阿司匹林联合氯吡格雷治疗大脑中动脉狭窄脑梗死的临床效果及用药安全性。方法将本院神经内科收治的90例急性大脑中动脉狭窄脑梗死患者根据入院顺序随机分为对照组和治疗组,每组各45例,其中对照组口服阿司匹林,治疗组在对照组治疗方案的基础上加用氯吡格雷,均以2个月为1个疗程,1个疗程结束后比较两组患者改良Fugl-Meyer上肢体综合功能评分、改良Barthel指数评分以及脑梗死进展率、复发率。结果两组患者VAS、Fugl-Meyer、Barthel指数评分比较,差异有统计学意义(P<0.05),治疗组优于对照组;治疗组脑梗死进展率、复发率低于对照组(P<0.05)。结论阿司匹林联合氯吡格雷治疗急性大脑中动脉狭窄脑梗死的效果明显,可提高患者的生活质量,缩短患者重返社会的时间。

Objective To analyze the clinical curative effect and drug safety of aspirin combined with clopidogrel in the cerebral infarction of middle cerebral artery stenosis. Methods 90 patients with cerebral infarction of acute middle cerebral artery stenosis who received and cured of neurology department in our hospital were randomly divided into control group and treatment group according to admission order,45 cases in each group.The control group had oral as- pirin therapy,the treatment group plus clopidogrel on the basis of the control group,all the patients had 4 weeks for a period of treatment,then compared modified Fugl-Meyer comprehensive function score,modified Barthel index score and the cerebral infarction progress rates and recurrence rates of the two groups of patients after the treatment. Results The VAS,Fugl-Meyer,Barthel index score were statistical differently between the two groups of patients （P〈0.05）,treatment group was superior to control group.Cerebral infarction recurrence rate and progress rates of treatment group were lower than those of the control group （P〈0.05）. Conclusion Aspirin combined with clopidogrel had significant curative effect in the cerebral infarction of acute middle cerebral artery stenosis,can ideally improve the patients＇ quality of life,short- en the time of the patients return to society.