生化标志物联合检测在急性冠脉综合征诊断中的临床意义

Clinical value of combined detection of biochemical markers in the diagnosis of acute coronary syndrome

目的探讨生化标志物联合检测在急性冠脉综合征诊断中的临床意义。方法检测50例急性冠脉综合征患者、30例健康体检者的CRP、IL-6、P-选择素、ICAM-1、MMPs-1的水平。结果观察组的CRP、IL-6、P-选择素、ICAM-1、MMPs-1阳性率均显著高于对照组(P<0.05)。CRP、IL-6、P-选择素、ICAM-1、MMPs-1联合检测阳性率显著高于各项单独检测阳性率(P<0.05)。结论生化标志物的联合检测有助于急性冠脉综合征患者的早期诊断,值得推广应用。

Objective To study the clinical value of combined detection of biochemical markers in the diagnosis of a- cute coronary syndrome.Methods 50 patients with acute coronary syndrome and 30 healthy adults were recruited.CRP, IL-6,P-selection,ICAM-1,MMPs-1 in two groups was measured rspectively.Resuits CRP,IL-6,P-selection,ICAM-1, MMPs-1 in observation group was significantly higher than that in control group respectively （P〈0.05）.The combined detection positive rate of CRP,IL-6,P-selection,ICAM-1 and MMPs-1 was significantly higher than that of single de- tection respectively （P〈0.05）.Conclusion The combined detection of biochemical markers might be helpful for the early diagnosis of acute coronary syndrome,it is worthy of promotion and application.