2型糖尿病患者糖化血红蛋白与抑郁症发病的相关性

The relationship between HbA1c and depression in patient with type 2 diabetes

目的探讨2型糖尿病患者糖化血红蛋白(HbA1c)与抑郁症发病的相关性。方法选取2型糖尿病患者170例分为两组,其中观察组(HbA1c≥7%)76例,对照组(HbA1c<7%)94例。检测所有患者的HbA1c、空腹血糖、血脂、肌酐、尿酸、尿素氮水平。结果两组的性别、年龄、饮酒、尿酸、BMI、血脂等比较差异无统计学意义(P>0.05)。观察组的抑郁症发病率、尿素氮及肌酐水平高于对照组,差异有统计学意义(P<0.05)。结论 HbA1c高的患者抑郁症发病率高,糖尿病患者应严格控制血糖,对于合并抑郁症者,应积极控制抑郁情绪,以改善预后和减少不良结局。

Objective To study the relationship between HbAlc and depression in patient with type 2 diabetes. Meth- otis 170 cases of type 2 diabetes were selected and divided into two groups.76 cases of observation group （HbAlc I〉 7%） and 94 cases of control group （HbAlc〈7%）.HbAlc,fasting plasma glucose,blood lipids,creatinine,uric acid and urea nitrogen was measured respectively. Results Gender,age,drinking,uric acid,blood lipid,BMI in two groups was com- pared respectively,with no statistical dufference （P〉0.05）.Incidence rate of depression,urea nitrogen and creatinine in observation group was higher than that in control group,with statistical dufference （P〈0.05）. Conclusion Patients with high HbAlc and high rate of depression.Diabetic patients should be strict control of blood glucose,for patients with de- pression,should be actively controlled depression,improve the prognosis and reduce adverse outcome.