胃癌患者辨证分型与血清EGFR水平的相关性研究

Correlation between the syndromes of patients with gastric carcinoma and levels of serum EGFR

目的探讨胃癌患者辨证分型与血清EGFR水平之间的关系。方法临床收集86例不同证型胃癌患者,ELISA测定血清EGFR水平,SPSS16.0软件分析胃癌证型与血清EGFR水平的相关性。结果气血两虚与瘀血内阻证以及湿热蕴毒与瘀血内阻证之间患者血清EGFR表达水平差异显著(P<0.05)。性别分层分析显示,男性胃热阴伤与瘀血内阻证以及湿热蕴毒与瘀血内阻证之间患者血清EGFR表达水平差异显著(P<0.05)。女性患者中任意两种证型之间比较,血清EGFR表达水平均无显著差异(P>0.05)。结论血清EGFR水平与胃癌患者辨证分型存在相关性,可作为辅助胃癌辨证分型的微观分子指标。

Objective To explore the correlation between the syndromes of patients with gastric carcinoma and levels of serum EGFR. Methods Clinical collected 86 cases of different syndromes of patients with gastric carcinoma. Serum levels of EGFR were measured by ELISA. The correlation between the syndromes of gastric cancer and levels of serum EGFR were analyzed by SPSS16. 0 software. Results In line with the levels of serum EGFR, there were significant differences between two pairs of syndrome types （ P 〈 0.05 ）, for example, the syndrome type of deficiency of both qi and blood and the syndrome type of interior retention of bloodstasis, the syndrome type of damp - heat with toxin and the syndrome type of interior retention of blood stasis. Gender stratification analysis showed that the level of serum EGFR between the syndrome type of impairment of yin due to stomach heat and the syn- drome type of interior retention of blood stasis, the syndrome type of damp - heat with toxin and the syndrome type of interior reten- tion of blood stasis differ significantly（P 〈 0.05） in men. Parallel comparison of the results of any two syndrome types of female patients was also analyzed, but no significantly differences were observed （ P 〉 0.05 ）. Conclusion Levels of serum EGFR were correlated with syndrome typing and could be used as the microscopic molecular markers for auxiliary syndrome differentiation of gastric cancer.