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EZH2基因与恶性肿瘤侵袭和转移关系的研究进展 被引量：4

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摘要 果蝇Zeste基因增强子人类同源物2（EZH2）是核心蛋白复合体-2（PRC2）的催化亚基,具有组蛋白甲基转移酶活性,它通过对组蛋白H3K27位点赖氨酸进行甲基化修饰发挥沉默靶基因的作用,从而导致肿瘤的发生.研究显示,EZH2在多种恶性肿瘤中表达广泛增高,并通过促进肿瘤细胞的增殖、细胞周期阻滞、细胞迁移和侵袭能力参与肿瘤的发生与演进,而且临床上EZH2异常表达与肿瘤侵袭性及较差预后相关,因此EZH2是肿瘤治疗的潜在靶点.现将主要针对EZH2基因与肿瘤的侵袭与转移研究的进展进行综述.
作者 张灵秀 孟凡义
机构地区 南方医科大学南方医院血液科
出处 《国际输血及血液学杂志》 CAS 2014年第2期163-167,共5页 International Journal of Blood Transfusion and Hematology
关键词 EZH2 肿瘤 侵袭 转移
分类号 R730 [医药卫生—肿瘤]
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参考文献45

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二级参考文献38

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国际输血及血液学杂志
2014年 第2期

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