核周型抗中性粒细胞胞质抗体在溃疡性结肠炎患者中的意义

Significance of Perinuclear Anti-neutrophil Cytoplasmic Antibody in Patients with Ulcerative Colitis

背景：核周型抗中性粒细胞胞质抗体（pANCA）阳性是诊断溃疡性结肠炎（UC）的特异性指标,但与疾病严重程度和疾病分期的相关性有待进一步研究.目的：探讨pANCA在UC患者中的意义.方法：选取2008年1月～ 2012年9月北京军区总医院125例UC患者,采用间接免疫荧光法检测血清pANCA,回顾性分析其与临床特征的相关性.结果：UC患者血清pANCA阳性率显著高于健康对照组（51.2％对0,P＜0.05）.活动期UC血清pANCA阳性率显著高于缓解期（57.9％对11.1％,P＜0.05）,而不同临床类型、严重程度、病变范围之间无明显差异（P＞0.05）.结论：UC患者血清pANCA阳性率可能与疾病分期有关,与临床类型、严重程度、病变范围等无关.

Background：The positive perinuclear anti-neutrophil cytoplasmic antibody （pANCA） is a specific indicator of ulcerative colitis （UC）.The relationship between positivity rate of pANCA and severity and staging of UC is needed to be further studied.Aims：To investigate the significance of pANCA in patients with UC.Methods：A total of 125 patients with UC from Jan.2008 to Sept.2012 at Beijing Military General Hospital were enrolled.Positivity of serum pANCA was detected by indirect immunofluorescence,and its correlation with clinical characteristics of UC was retrospectively analyzed.Results：The positivity rate of serum pANCA in patients with UC was significantly higher than that in controls （51.2% vs.0,P 〈 0.05）.Positivity rate of serum pANCA in active UC was significantly higher than that in remissive UC （57.9% vs.11.1%,P 〈 0.05）,however,no significant difference was found between UC with different clinical type,severity and lesion location （P 〉 0.05）.Conclusions：Positivity of serum pANCA in UC patients may be correlated with staging,but not with clinical type,severity and lesion location.