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口腔扁平苔藓组织中HERG1和Kv3.4钾离子通道蛋白的表达 被引量：2

Expression of HERG1 and Kv3.4 in oral lichen planus
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摘要 目的:研究钾离子通道蛋白HERG1、Kv3.4在口腔扁平苔藓(oral lichen planus,OLP)中的表达及意义。方法:采用免疫组织化学SP技术检测20例OLP和16例正常口腔黏膜(normal oral mucosa,NOM)组织中HERG1及Kv3.4的表达。结果:HERG1和Kv3.4在NOM、非糜烂型OLP组织表达阴性或基底层有少量表达;在糜烂型OLP基底层、棘细胞层及颗粒层呈阳性表达;HERG1、Kv3.4在OLP组织的表达均高于正常组织(P<0.05),且糜烂型OLP中的表达高于非糜烂型OLP(P<0.05);在OLP中HERG1与Kv3.4的表达呈正相关(P<0.05)。结论:HERG1、Kv3.4可能与OLP的发生发展有关。 Objective：To investigate the expression of HERG1 and Kv3.4 in normal oral mucosa（NOM）and oral lichen planus （OLP）.Methods：20 OLP and 1 6 NOM specimens were collected and immunohistochemically stained（IHC）by SP method for the detection of HERG1 and Kv3.4 protein expression.Results：HERG1 and Kv3.4 were negative or weak-positive in the sapmles of bas-al layer of NOMand non-erosive OLP,but positive in basal layer,spinous layer and granular layer of erosive OLP.The expression of HERG1 and Kv3.4 was higher in OLP than in NOM tissues （P 〈0.05）;and higher in erosive OLP than in non-erosive OLP（P 〈0.05）.In OLP HERG1 expression was positively related to Kv3.4（P 〈0.05）.Conclusion：HERG1 and Kv3.4 may be related to the development of OLP.
作者 缪克红 聂敏海 宋成成 宋萍萍 伍宝琴
机构地区 自贡市第一人民医院口腔科 泸州医学院附属口腔医院口腔内科
出处 《实用口腔医学杂志》 CAS CSCD 北大核心 2014年第2期206-210,共5页 Journal of Practical Stomatology
关键词 口腔扁平苔藓 HERG1 Kv3 4 钾离子通道 Oral lichen planus HERG1 Kv3. 4 Potassium channel
分类号 R781.5 [医药卫生—口腔医学]
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参考文献23

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共引文献20

同被引文献30

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二级引证文献5

实用口腔医学杂志
2014年 第2期

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