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口腔扁平苔藓组织中HERG1和Kv3.4钾离子通道蛋白的表达 被引量:2

Expression of HERG1 and Kv3.4 in oral lichen planus
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摘要 目的:研究钾离子通道蛋白HERG1、Kv3.4在口腔扁平苔藓(oral lichen planus,OLP)中的表达及意义。方法:采用免疫组织化学SP技术检测20例OLP和16例正常口腔黏膜(normal oral mucosa,NOM)组织中HERG1及Kv3.4的表达。结果:HERG1和Kv3.4在NOM、非糜烂型OLP组织表达阴性或基底层有少量表达;在糜烂型OLP基底层、棘细胞层及颗粒层呈阳性表达;HERG1、Kv3.4在OLP组织的表达均高于正常组织(P<0.05),且糜烂型OLP中的表达高于非糜烂型OLP(P<0.05);在OLP中HERG1与Kv3.4的表达呈正相关(P<0.05)。结论:HERG1、Kv3.4可能与OLP的发生发展有关。 Objective:To investigate the expression of HERG1 and Kv3.4 in normal oral mucosa(NOM)and oral lichen planus (OLP).Methods:20 OLP and 1 6 NOM specimens were collected and immunohistochemically stained(IHC)by SP method for the detection of HERG1 and Kv3.4 protein expression.Results:HERG1 and Kv3.4 were negative or weak-positive in the sapmles of bas-al layer of NOMand non-erosive OLP,but positive in basal layer,spinous layer and granular layer of erosive OLP.The expression of HERG1 and Kv3.4 was higher in OLP than in NOM tissues (P 〈0.05);and higher in erosive OLP than in non-erosive OLP(P 〈0.05).In OLP HERG1 expression was positively related to Kv3.4(P 〈0.05).Conclusion:HERG1 and Kv3.4 may be related to the development of OLP.
出处 《实用口腔医学杂志》 CAS CSCD 北大核心 2014年第2期206-210,共5页 Journal of Practical Stomatology
关键词 口腔扁平苔藓 HERG1 Kv3 4 钾离子通道 Oral lichen planus HERG1 Kv3. 4 Potassium channel
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共引文献20

同被引文献30

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