不同质子泵抑制剂联合莫沙必利治疗返流性食管炎的效果对比研究

Comparative study on clinical efficacy of different proton pump inhibitors combined with Mosapride in the treatment of reflux esophagitis

目的 探讨不同质子泵抑制剂联合莫沙必利治疗返流性食管炎的有效性和安全性.方法 选取我院收治的202例返流性食管炎患者,随机均分为奥美拉唑组和雷贝拉唑组,奥美拉唑组给予奥美拉唑联合莫沙必利治疗,雷贝拉唑组给予雷贝拉唑联合莫沙必利治疗.比较两组患者治疗总有效率和不良反应发生率的差异.结果 雷贝拉唑组治疗总有效率为97.0％,显著高于奥美拉唑组的86.1％ （P＜0.05）;两组患者均无严重不良反应发生,不良反应发生率比较差异无统计学意义（P＞0.05）.结论 雷贝拉唑联合莫沙必利治疗返流性食管炎疗效确切,无严重不良反应,值得临床广泛推广使用.

Objective To investigate the clinical efficacy and safety of different proton pump inhibitors combined with Mosapride in the treatment of reflux esophagitis.Methods 202 cases of reflux esophagitis in our hospital were randomly divided into Omeprazole group and Rabeprazole group.Omeprazole group received Omeprazole combined with Mosapride treatment,while Rabeprazole group received Rabeprazole combined with Mosapride treatment.The total effective rate and incidence of adverse reactions in two groups were compared.Results The total effective rate in Rabeprazole group was 97.0%,significantly higher than 86.1% in Omeprazole group （P 〈 0.05）.No serious adverse reaction occurred in two groups.Conclusion Rabeprazole combined with Mosapride in the treatment of reflux esophagitis is effective,without serious adverse reactions,worthy of clinical wide application.