糖尿病足发生相关风险性因素的临床观察

Clinical observation on risk factors of diabetic foot

目的通过观察糖尿病足患者临床相关指标的变化,探讨糖尿病足发生发展的相关危险因素。方法将134例观察对象分为非糖尿病足组(NDF)及糖尿病足组(DF)2组,观察随访期间患者血糖、糖化血红蛋白(HbA1c)、肌酐、尿酸、尿微量白蛋白等指标的变化情况及糖尿病其他并发症发生情况。结果 2组患者血糖水平无明显差异(P>0.05);DF组患者的HbA1c水平较高,差异具有统计学意义(P<0.05);DF女性组与NDF女性组比较,其尿酸水平较高,且具有统计学差异(P<0.05)。DF组尿微量白蛋白与NDF组比较具有统计学差异(P<0.05),但血清钾、血清钠等生化指标之间无明显差异(P>0.05)。结论临床上可通过观察HbA1c、尿酸、尿微量白蛋白等指标的变化,及早预测及干预糖尿病足发生。

Objective To investigate the risk factors of diabetic foot by observing the changes of the relative index. Methods 134 pa-tients were randomly divided into non-diabetic foot （NDF） group and diabetic foot （DF） group,the changes of blood glucose,HbA1c,creati-nine,uric acid,microalbuminuria and the complications of diabetes were observed. Results There no difference in blood glucose level be-tween 2 groups （P〉0. 05）. The HbA1c levels of DF group was higher,with a significant difference（P〈0. 05）. The levels of uric acid in fe-male of DF group was higher than those in female of NDF group（P〈0. 05）. there was significant differernces in levels of microalbuminuria （P〈0. 05）,but no statistic difference in levels of potassium and sodium between 2 groups. Conclusion The changes of HbA1c,uric acid and microalbuminuria could indicate the diabetic foot in clinic.