依地酸二钠钙联合水溶性维生素对治疗铅中毒的疗效观察

Therapeutic effect of combined calcium disodium edetate and water-soluble vitamins on lead poisoning

目的探讨治疗铅中毒患者最有效的方法。方法选择100名慢性职业性轻度铅中毒患者为实验组,以静脉滴注水溶性维生素和依地酸二钠钙为主,并补充钙、铁等微量元素;另外选择100名慢性职业性轻度铅中毒患者为对照组,以静脉滴注依地酸二钠钙为主,并补充钙、铁等微量元素,分别测定两组人员治疗第一疗程后体内尿铅和血铅浓度,观察临床表现的改善。结果实验组患者体内尿铅和血铅浓度均低于对照组(t=5.38、6.20,P<0.01),第一疗程驱铅成功率高于对照组(χ2=56.21,P<0.01),同时临床表现改善率也高于对照组(χ2=63.78,P<0.01)。结论水溶性维生素对治疗铅中毒有一定的疗效,可考虑推广使用。

Objective To explore the most effective treatment method for chronic lead poisoning patients. Methods A total of 100 patients diagnosed as occupationally chronic mild lead poisoning were treated as the experimental group with intravenous infusion of water-soluble vitamins and calcium disodium edetate,plus calcium,iron and other trace elements. Another group of 100 cases were treated as the control group with intravenous infusion of disodium edetate calcium,plus calcium,iron and other trace elements,without water-soluble vitamins. The lead level in both urine and blood and the clinical manifestation were obseived after the first course of treatment. Results The patients＂ lead level in both urine and blood was significantly lower in the experimental group compared with the control group （t = 5.38,6.20; P 〈 0.01）,while clinical manifestation was significantly improved （X2 = 63.78, P 〈 0.01 ）. Conclusion The use of water-soluble vitamins was helpful and effective for the treatment of lead poisoning.