桂枝茯苓丸治疗子宫肌瘤的疗效及对hs-CRP的影响

Clinical Efficacy of GuiZhifuling Pills Treatment Uterine Fibroids and The Impact of Serum Hs-CRP

目的:探讨桂枝茯苓丸治疗子宫肌瘤的临床疗效观察及对患者血清hs-CRP的影响。方法:选取104例符合本次临床研究的患者,随机分为两组,对照组62例,从月经来潮的第一天起开始给予米非司酮片12.5mg,1次/日,口服。治疗组患者在月经干净后,在对照组的基础上同时加服桂枝茯苓丸4g/次,2次/日,口服,连服3个月。观察患者子宫肌瘤大小、症状体征、患者hs-CRP变化及安全性分析。结果:两组治疗后与治疗前组内相比,子宫肌瘤体积均明显缩小、hs-CRP明显降低,有显著性差异(P<0.01),血红蛋白明显升高,有显著性差异(P<0.05);治疗后两组组间比较,治疗组子宫肌瘤体积缩小、hs-CRP降低明显优于对照组(P<0.01),血红蛋白两组未见明显差异(P>0.05);治疗后两组总体有效率比较,治疗组明显优于对照组(P<0.05)。结论:桂枝茯苓丸治疗子宫肌瘤疗效确切,能明显缩小子宫肌瘤瘤体,并且能降低患者血清hs-CRP,减轻炎症反应。

Objective：Explore the clinical efficacy of GuiZhifuling pills treatment uterine fibroids and the impact of serum hs-CRP. Methods：Selected 104 patients who met the clinical study of patients were randomly divided into two groups.The control group of 62 patients, starting from the first day of the menstrual cramps given mifepristone tablets 12.5mg/day, oral.Patients treated with clean after menstruation, on the basis of the control group at the same time plus service GuiZhifuling pills 4g/2 times/day, oral, 3 months of treatment. Observed in patients with uterine fibroids the size of signs and symptoms, patients with hs-CRP change and security analysis. Results：Groups after treatment than before treatment group, uterine fibroid volume were significantly reduced, hs-CRP decreased significantly. there is a significant difference （P〈0.01）, hemoglobin was significantly higher, there is a significant difference （P〈0.05）;after treatment between the two groups, the saller uterine fibroids and hs-CRP decreased significantly of treatment group is better than the control group （P〈0.01）, hemoglobin two groups showed no significant difference （P〉0.05）;After treatment, over all efficiency compared with the treatment group was significantly better than the control group （P〈0.05）. Conclusion：The GuiZhifuling pills treatment the the uterine fibroids curative effect, can significantly shrink uterine fibroid tumors,and reduce serum hs-CRP, and reduce inflammation.