慢性阻塞性肺疾病患者血清胎盘生长因子的水平变化分析

PIGF level in patients with chronic obstructive pulmonary disease and its significance

目的探讨胎盘生长因子(placental growth factor,PIGF)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者中的水平变化及临床意义。方法选取2011年1月—2012年3月治疗的COPD患者60例,其中稳定期患者30例为稳定组,急性加重期患者30例为急性组,选取肺功能检测正常的同期健康查体者30例为对照组。所有受试者先行肺功能通气检查,肺功能测定有专业人员行标准化操作。ELISA测定血清中PIGF水平。计量资料用x±s表示,各组间均数比较采用单因素方差分析,相关性分析采用Pearson相关分析。取t=0.05为检验水准,P<0.05为差异有统计学意义。结果稳定组、急性组血清PIGF水平[(28.38±9.49)、(36.88±12.47)pg/ml]均显著高于对照组,1 s用力呼气容积占预计值百分比(forced expiratory volume in one second to predicted value ratio,FEV1%)(59.52±17.65、53.02±18.39)低于对照组,比较差异均有统计学意义(均P<0.05);急性组血清PIGF水平高于稳定组,比较差异有统计学意义(P<0.05)。急性组血清PIGF水平与FEV1%预计值呈负相关(r=-0.506,P<0.05);稳定组血清PIGF水平与FEV1%预计值呈负相关(r=-0.601,P<0.05)。结论 COPD急性加重期、稳定期患者血清PIGF水平均升高,且与COPD的严重程度呈正相关,PIGF可能在COPD发病机制中起一定作用。

Objective To discuss the change of placental growth factor（PIGF） level in chronic obstructive pulmonary dis- ease （COPD） and its clinical significance. Methods Sixty cases of COPD were selected from January 2011 to March 2012 enrolled, including 30 cases of stable COPD and 30 cases of acute exacerbation of COPD. 30 cases of healthy controls with normal lung function were also included. All the subjects were firstly tested for their ventilatory function of the lungs, which was performed by specialized professionals. ELISA was used to determine the level of PIGF. Measurement data were represented by ~ -＋ s. One - way analysis of variance was used for means between groups and Pearson~ analysis for correla- tion. T = O. 05 as size of test, the result of P 〈 0.05 was considered statistically significant. Results Serum level of PIGF was （28.38 ＋ 9.49）and（36.88 ＋ 12.47 ）pg/ml respectively in group with stable COPD and group with exacerbated COPD, which was significantly higher than that in normal controls, FEV1% was （59.52 ＋ 17.65 ） and （53.02 ＋ 18.39） respectively in group with stable COPD and group with exacerbated COPD, which was lower than that in normal controls, and there was statistically significant difference（ P 〈 0.05）. The level of PIGF in group with exacerbated COPD was significantly higher than that in group with stable COPD, and there was statistically significant difference （ P 〈 0.05 ）. The level of PIGF in group with exacerbated COPD was negatively correlated with FEV1% （ r = - 0. 506, P 〈 0.05 ） ; the level of PIGF in group with stable COPD was negatively correlated with FEVI % （r = -0. 601, P 〈 0.05）. Conclusions The level of PIGF in pa- tients with acute exacerbation and stable COPD is higher than that in normal controls and is positively correlated with dis- ease severity. PIGF may be involved in the pathogenesis of COPD.