ω-3多不饱和脂肪酸代谢途径工程研究进展

Research Progress of Metabolic Pathway Engineering of ω-3 PUFAs

ω-3多不饱和脂肪酸(ω-3 PUFAs)是人体生长和健康所必需的物质,对人体免疫系统、心血管系统和神经系统等疾病有着理想的预防和治疗功效,市场需求量大。然而,由于ω-3 PUFAs主要提取自深海鱼油,资源相对匮乏且环境污染导致鱼中含有重金属和二噁英等毒性物质,因此,迫切需要寻找新的可持续资源生产ω-3 PUFAs。随着现代生物技术的发展,可利用代谢途径工程提高ω-3 PUFAs产量,本文着重阐述利用代谢途径工程技术解决ω-3 PUFAs资源匮乏问题的研究进展。

ω-3 polyunsaturated fatty acids （ω-3 PUFAs） are taken seriously for its important role in human health. More and more ω-3 PUFAs are needed for its ideal prephylaxis and treatment effects on immune system, cardiovascular system and nervous system diseases. However, the resource of ω-3 PUFAs is relatively scarce because it was mainly extracted from fish oil which is polluted by toxic substances such as heavy metals and dioxins. Therefore, it is urgent to find new sustainable resources to produce ω-3 PUFAs. With the development of modem biotechnology, through metabolic pathway engineering to improve the production of ω-3 PUFAs becomes possible. In this review, we mainly elaborated the research progress of metabolic pathway engineering of ω-3 PUFAs.