上海市徐汇区住院患者血中维生素D水平分析

Analysis of Serum Vitamin D Level in Inpatients in Shanghai Xuhui District

目的：调查上海市徐汇区住院患者血中维生素D水平。方法：上海市徐汇区中心医院2（）12年5月～2（）13年1月收治2315例住院患者。采用液相色谱质谱联用法（LC-MS／MS）测定患者的血清25羟基维生素D2[25（OH）D1]、25-羟基维生素D2[25（OH）D，]，同时采用常规生化法测定患者的甲状旁腺素（PTH）水平。结果：受试者的25（OH）D2血清浓度为（1．58±2．08）ng／mL，25（OH）I）3为（14．23±7．47）ng／mL，总25-羟基维生素D[25（OH）D，包括25（OH）D2和25（OH）U]为（15．81±7．98）ng／mL，PTH为（48．92±28．65）pg／mL。各年龄段中，大于9（j岁受检者的25（OH）D浓度最低，其次为小于4（）岁者，而60～69岁组最高。1787例（77．19％）受试者的PTH血清浓度正常[（10～65）pg／mL]，相对应的25（OH）D2为（1．62±2．02）ng／mL，25（OH）D3为（4．62±7．06）ng／mL，25（OH）D血清浓度为（16．24±7．28）ng／mL，PTH与25（OH）D呈负相关（pesrsorl相关系数为-0．212，P〈0．01）。结论：上海市徐；I-区住院患者的维生素D水平普遍偏低。

Objective：To investigate the serum vitamin D level in inpatients in Shanghai Xuhui District. Methods：The serum 25 hydroxyvitamin D2 [- 25（OH）D2 ] and 25 hydroxyvitamin D3 [25（OH）D3 ] levels of 2315 patients in Shanghai Xuhui District Central Hospital from May 2012 to Jan 2013 were measured by liquid chromatography tandem mass spectrometry（LC-MS/ MS）. And the levels of serum PTH in all patients were examined simultaneously by routinely biochemical method. Results： In all the patients, the mean level of 25（OH）D2 was （1.58 ±2.08） ng/mL, the mean level of 25（OH）D3 was （14.23 ± 7.47） ng/ mL, the mean level of total 25 hydroxyvitamin I）[-25（OH）D] was （15.81 ± 7.98） ng/mL, the mean level of parathyroid hor- mone（PTH） was （48.92± 28.65） pg/mL. For all age groups, the mean concentration of 25（OH）D in patients above 90 years old was the lowest, followed by subjects below 40 years old, while that in the 60-69 years old subjects was the highest. PTH concentrations in 1787 patients （77.19%） were in the normal range （10-65 pg/mL）, in whom, the levels of 25（OH）D2, 25（OH）D3 and 25（OH）D were （l.62±2.02）ng/mL, （4.62±7.06） ng/mL and （16.24±7.28） ng/mL. The level of PTH was negatively correlated with the level of 25 （OH）D, and the correlation coefficient was 0. 212（P〈0. 01 ）. Conclusions： Vita min D deficiency is a quite serious problem in Shanghai Xuhui District inpatients.