颈动脉粥样硬化、低密度脂蛋白与糖尿病大血管病变所致急性心肌梗死的关系

The correlations between carotid atherosclerosis /low- density lipoprotein and acute myocardial infarction caused by diabetic vascular lesions

目的探究颈动脉粥样硬化、低密度脂蛋白与糖尿病大血管病变所致急性心肌梗死的关系。方法回顾性分析2012年5月至2013年11月期间我院内科收治的42例2型糖尿病存在大血管病变并致急性心梗死患者的临床资料。结果观察组颈总动脉内径、颈动脉内-中膜厚度的测量值均高于对照组,同时粥样斑块发生率及个数均高于对照组;且观察组多为Ⅲ级、Ⅳ级斑块,而对照组均为Ⅱ级斑块;另外,空腹血糖和低密度脂蛋白水平均高于对照组,组间比较差异具有统计学意义,P<0.05。结论研究颈动脉粥样硬化、低密度脂蛋白与糖尿病慢性并发症大血管病变的关系,可为指导启动心脑血管一、二级预防提供临床依据,也可作为二级预防的疗效观察。

Objective To explore the correlations between carotid atherosclerosis /low -density lipoprotein and acute myocardial infarction caused by diabetic vascular lesions . Methods Retrospectively analyzethe datas of 42 patients those who suffered from type 2 diabetes and vascular disease and secondary with acute cardiac infarction during May 2012and November 2013.Results The arteria carotis communis diameter and carotid artery intema/media thickness of observation group were higher than those of control group , so did the incidence and number of atheromatous plaque .Most of the atheromatous plaque in observation group were gradeⅢ/Ⅳ,but all the atheromatous plaque in control group were grade Ⅱ.In addition, the concentration of fasting plasma glucose and LDL levels of observation group were were higher than those of control group , the difference between groups was statistically significant （ P ＆lt;0.05 ）. Conclusions The correlation between carotid atherosclerosis/LDL and acute myocardial infarction caused by diabetic vascular lesions could provide clinical guidance for grade I/Ⅱpreventing for cardiovascular disease , can also be used as efficacy assessment of secondary prevention .