无形体病的临床研究

Clinical study on anaplasmosis

目的研究无形体病的流行病学、临床表现、误诊、治疗及预后。方法对243例发热病因待查患者的血清进行无形体IgM、IgG及PCR检测,回顾性地总结阳性病历特点。结果发现11例血清抗体阳性患者,流行病史无特殊,临床表现以发热、畏寒、头痛、皮疹常见,血白细胞减少,肝功多受损,既往多误诊为病毒感染,抗感染仅四环素、多西环素有效,预后良好。结论无形体病在发热病因待查患者中占有一定比例,应引起临床医师关注。

Objective To study the epidemological features, clinical manifestation, misdiagnosis, treatment and prognosis of anaplasmosis. Methods Two hundred and forty - three eases of fever patients with unknowing cause were conducted the serum IgM, IgG and PCR test of anaplasma. The positive cases were analyzed to summarize the disease characteristics. Results E- leven positive cases were found in total, and there was no special epidemiology history. Fever, chilly, headache, skin rash, leukopenia and liver injury were common clinical manifestations, wihch were always misdiagnosed as viurs infection. Only doxy- cycline and tetracycline were effective for treament with good prognosis, while the rest antibiotics were useless. Conclusion Anaplasmosis cases take a certain proportion in fever patients with unknowing cause, needing more concern from the physicians.