瘦素在非肌层浸润性膀胱癌中的表达及其意义

Expression of Leptin in Non-muscle-invasive Bladder Cancer and Its Significance

[目的]探讨瘦素在非肌层浸润性膀胱癌中的表达情况,组织并分析其与膀胱癌患者临床病理特征及预后的关系。[方法]收集112例膀胱移行细胞癌组织和20例正常膀胱组织的病理切片,采用免疫组化方法检测膀胱癌和正常膀胱组织中瘦素的表达。[结果]正常膀胱组织中瘦素的表达水平明显低于肿瘤组织(P=0.032)。在低级别、高级别膀胱癌中,瘦素的阳性表达率分别为43.8%、75.8%,差别有统计学意义(P=0.001)。本组随访6～102个月,其中67例出现复发。复发组与未复发组中瘦素的阳性表达率分别为70.1%和46.7%,差别有统计学意义(P=0.013)。但瘦素表达与患者年龄、性别、肿瘤数目、大小及分期无明显相关性(P>0.05)。[结论]瘦素表达在膀胱癌组织中明显高于正常膀胱组织,瘦素的检测有助于膀胱癌诊断及预后评估。

[Purpose] To investigate the expression of leptin in non-muscle-invasive bladder cancer and its relationship with clinical features and prognosis. [Methods] The expression of leptin in 112 specimens of non-muscle-invasive bladder cancer and 20 specimens of normal bladder tissues was detected by immunohistochemtry. [Results] The positive rate of leptin was significantly higher in bladder cancer tissues than that in normal bladder tissues （P=0.032）. The positive rate of leptin was 43.8% in low grade bladder cancer,75.8% in high grade,with significant difference（P=-0.001）. The patients were followed up for 6~102 months,and 67 patients were recurrent. The expression of leptin was significantly higher in recurrence group than that in non-recurrence group （70.1% vs 46.7% ,P=0.013）. The positive rate of leptin related to tumor grade and recurrence （P〈0.05）,but not with sex,age,tumor number, size and stage （P〉0.05）. [Conclusionl The expression of leptin is higher in superficial bladder cancer. The detection of the expression of leptin is helpful to diagnosis and prognostic evaluation in non-muscle-invasive bladder cancer.