摘要
Cancer cells are well documented to rewire their metabolism and energy production networks to support and enable rapid proliferation, continuous growth, survival in harsh conditions, invasion, metastasis, and resistance to cancer treatments. Since Dr. Otto Warburg's discovery about altered cancer cell metabolism in 1930, thousands of studies have shed light on various aspects of cancer metabolism with a common goal to find new ways for effectively eliminating tumor cells by targeting their energy metabolism. This review highlights the importance of the main features of cancer metabolism, summarizes recent remarkable advances in this field, and points out the potentials to translate these scientific findings into life-saving diagnosis and therapies to help cancer patients.
Cancer cells are well documented to rewire their metabolism and energy production networks to support and enable rapid proliferation, continuous growth, survival in harsh conditions, invasion, metastasis, and resistance to cancer treatments. Since Dr. Otto Warhurg＇s discovery about altered cancer cell metabolism in 1930, thousands of studies have shed light on various aspects of cancer metabolism with a common goal to find new ways for effectively eliminating tumor cells by targeting their energy metabolism. This review highlights the importance of the main features of cancer metabolism, summarizes recent remarkable advances in this field, and points out the potentials to translate these scientific findings into life-saving diagnosis and therapies to help cancer patients.
基金
supported by the National Institutes of Health through The University of Texas MD Anderson Cancer Center’s Support Grant CA016672
National Cancer Institute grant RO1CA 089266 (MHL)
Directed Medical Research Programs Department of Defense Synergistic Idea Development Award BC062166 (SCY, MHL)
the Susan G.Komen Breast Cancer Research Foundation Promise Grant KG081048 (SCY, MHL)
Vietnam Education Foundation, Rosalie B.Hite Foundation
Department of Defense Breast Cancer Research Program (Award # W81XWH-10-0171)
