Annexin A2及CD_(105)在胰腺导管腺癌中的表达及临床意义

Expression of Annexin A2 and CD_(105) in pancreatic ductal adenocarcinoma and their clinical significance

目的：探讨Annexin A2（ANXA2,膜联蛋白A2）及CD105在胰腺导管腺癌中表达及两者的相关性。方法采用免疫组织化学染色检测胰腺导管腺癌及癌旁组织中Annexin A2的表达情况及MVD,并对结果进行相关性分析。结果 Annexin A2在肿瘤组织中表达的阳性率显著高于癌旁组织（P＆lt;0.05）,且癌组织中Annexin A2的表达强度高于癌旁组织（P＆lt;0.05）。低分化癌组织Annexin A2表达的阳性率高于高分化和中分化癌组织的阳性率。Annexin A2的表达与癌组织的淋巴转移相关。胰腺导管腺癌组织中的MVD明显高于癌旁组织（P＆lt;0.05）。同时, MVD随癌组织分化程度的增高而降低。TNM分期的Ⅲ-Ⅳ期明显高于Ⅰ-Ⅱ期（P＆lt;0.05）。CD105标记的MVD与癌组织的淋巴转移相关。Annexin A2染色3＋的癌组织MVD明显低于Annexin A2染色0、1＋、2＋（P＆lt;0.05）,但Annexin A2染色0、1＋、2＋的癌组织的MVD表达差异无统计学意义（P=0.615、0.243、0.459）。结论 Annexin A2与CD105在胰腺导管腺癌组织中表达升高,且都与癌组织病理分级及淋巴转移相关。两者具有一定相关性。

Objective To explore the expression of Annexin A2 and CD105 in pancreatic ductal adenocarcinoma（PDAC） tissues and peficancerous tissues and their clinical significance. Methords Using immunohistochemical staining to detect the expression of Annexin A2 and CD105 in pancreatic cancerous tissues and peficancerous tissues, and conduct correlation analysis of results. Results The positive expression rate of Annexin A2 and the MVD in pancreatic ductal adenocarcinoma tissues was higher than that it in peficancerous tissues（P＆lt;0.05）, the express degree of Annexin A2 in cancerous tissues was higher than it in peficancerous tissues（P＆lt;0.05）. The expression of Annexin A2 and the MVD were correlated with histological grade and lymphatic metastasis（P＆lt;0.05）. The MVD of cancerous tissues in clinical stage Ⅲ-Ⅳwas significantly higher than that in clinical stageⅠ-Ⅱ（P＆lt;0.05）. The MVD of Annexin A2 dyeing 3＋cancerous tissue was significantly lower than those in other Annexin A2 dyeing grade（P＆lt;0.05）. Conclusion The expression of Annexin A2 and CD105 in PDAC is higher than it in peficancerous tissues, and two of both are correlated with hitological grade and lymphatic metastasis. There is correlation in both.