慢性乙型肝炎患者MDSC的含量测定及其免疫抑制作用

Content determination of MDSC for chrionic hepatitis B patients and its effect on the immune suppression

目的探讨并分析正常人对照组及慢性乙型肝炎患者外周血中MDSCs含量与病毒载体、疾病预后的关系。方法分别用流式细胞仪检测健康人和慢性乙型肝炎患者外周血MDSCs含量,并进行病毒载量和疾病预后资料的相关分析。结果慢性乙型肝炎组的MDSCs百分含量相与正常对照组相比,显著增多(P<0.05);而且通过病例资料分析发现MDSCs含量不仅随着慢性HBV病重程度逐级升高,而且与慢性乙肝疾病预后HBV-DNA含量密切相关。结论 MDSCs可作为慢性乙型肝炎的一种新型血清标志物,用于患者的诊断和预后指标。

Objective To investigate the relationship between the analysis and the normal control group and chronic hepatitis B in the peripheral blood of patients with viral vectors, MDSCs content and the prognosis of the disease. Methods Patients with healthy people were detected by flow cytometry and chronic hepatitis B, peripheral blood MDSCs content, correlation analysis and viral load and disease outcome data. Results the percentage of MDSCs phase and the chronic hepatitis B group compared with the normal control group, increased significantly （P〈0.05）;and through the case analysis found that MDSCs was not only with chronic HBV severity gradually increased, and closely related to chronic hepatitis B disease prognosis HBV-DNA content. Conclusion MDSCs can be used as a new type of chronic hepatitis B serum marker for diagnosis and prognosis, patients.