原发性胃肠道非霍奇金淋巴瘤51例临床分析

Primary gastrointestinal non-Hodgkin lymphoma： a retrospective study of 51 cases

目的 了解不同细胞来源原发性胃肠道非霍奇金淋巴瘤（PGINHL）的临床特征、诊断治疗及预后.方法 回顾性分析明确诊断的51例PGINHL病例资料,分析B细胞来源与T细胞来源的PGINHL的临床表现、诊断治疗,并随访其预后.结果 51例PGINHL患者中位年龄56岁,男女比例为1.44∶1,B细胞来源35例（68.7％）,T细胞来源16例（31.3％）.T细胞淋巴瘤较B细胞淋巴瘤患者便血、腹泻、盗汗发生率高（P＜0.05）;T细胞淋巴瘤较B细胞淋巴瘤患者总体预后差.黏膜相关组织淋巴瘤（MALT）预后最好,剔除MALT后,T细胞淋巴瘤与B细胞淋巴瘤患者预后差异无统计学意义（P＞0.05）.结论 在PGINHL患者中,B细胞来源淋巴瘤比例高,且预后好于T细胞淋巴瘤.

Objective To understand the clinical characteristics and treatment outcomes of primary gastrointestinal non-Hodgkin lymphomas （PGINHL） and analyze the differences between T-cell and B-cell lymphomas.Methods.The characteristics of 51 PGINHL patients were analyzed regarding to their clinical manifestations,diagnosis,treatments and outcomes.Results 51 cases of PGINHL meeting the WHO（2008） criteria were identified.The median age of the patients at the time of diagnosis was 56 years old and the male ∶ female ratio was 1.44∶1,35 cases （68.7 %） had B-lineage and 16 cases （31.3 %） had T-cell lineage lymphomas.Compared to those with B-cell lymphoma,patients with T-cell lymphoma presented with a greater incidence of such symptoms as hematochezia,diarrhea and night sweating （P 〈 0.05）.After eliminating MALT lymphoma,prognosis of T-cell lymphoma and B-cell lymphoma had no significant difference.Conclusion In PGINHL cases,B-cell lymphomas appeare to be more common and have better prognosis than T-cell lymphomas.