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组蛋白甲基转移酶EZH2在血液肿瘤中表观遗传调控作用的研究进展 被引量：3

Research progress of epigenetic regulation of histone methyltransferase EZH2 in hematologic neoplasms
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摘要 组蛋白甲基转移酶EZH2是特异性H3K27甲基转移酶,催化H3K27甲基化从而参与异染色质形成及基因转录调控.EZH2在多种肿瘤组织中表达异常增高,其具有癌基因的活性;EZH2在髓系肿瘤发生中也可起到抑癌基因的作用.文章重点阐述EZH2的结构特点、作用方式及与血液肿瘤的关系等,为以EZH2为靶点治疗血液肿瘤提供系统认识. The histone H3 lysine 27 methyltransferase EZH2 takes part in heterochromatin formation and gene transcription regulation.EZH2 is frequently over-expressed in a wide variety of cancerous tissue types,which reveals it to be oncogenic.However,in myeloid malignancies,EZH2 could act as a tumor suppressor.This paper mainly reviews the structure and function of EZH2 and its effect on hematologic neoplasms.Taking EZH2 as target will provide systematic understanding for the treatment of hematologic neoplasms.
作者 林璐慧 马旭东
机构地区 福建医科大学附属漳州市医院血液内科
出处 《白血病．淋巴瘤》 CAS 2014年第3期185-188,共4页 Journal of Leukemia & Lymphoma
关键词 血液肿瘤 EZH2 组蛋白甲基转移酶 表观遗传学 Hematologic neoplasms EZH2 Histone methyhransferase Epigenetic
分类号 R733 [医药卫生—肿瘤]
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参考文献39

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二级参考文献36

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白血病．淋巴瘤
2014年 第3期

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