摘要
组蛋白甲基转移酶EZH2是特异性H3K27甲基转移酶,催化H3K27甲基化从而参与异染色质形成及基因转录调控.EZH2在多种肿瘤组织中表达异常增高,其具有癌基因的活性;EZH2在髓系肿瘤发生中也可起到抑癌基因的作用.文章重点阐述EZH2的结构特点、作用方式及与血液肿瘤的关系等,为以EZH2为靶点治疗血液肿瘤提供系统认识.
The histone H3 lysine 27 methyltransferase EZH2 takes part in heterochromatin formation and gene transcription regulation.EZH2 is frequently over-expressed in a wide variety of cancerous tissue types,which reveals it to be oncogenic.However,in myeloid malignancies,EZH2 could act as a tumor suppressor.This paper mainly reviews the structure and function of EZH2 and its effect on hematologic neoplasms.Taking EZH2 as target will provide systematic understanding for the treatment of hematologic neoplasms.
出处
《白血病.淋巴瘤》
CAS
2014年第3期185-188,共4页
Journal of Leukemia & Lymphoma