3,3,6,6-四甲基-9-喹啉基-2,4,5,7,9,10-六氢化吖啶-1,8(2H,5H)-二酮衍生物的合成、晶体结构

Synthesis and Crystal Structure of 3,3,6,6-Tetramethyl-9-quinolyl-2,4,5,7,9,10-hexahydroacridine-1,8( 2H,5H)-dione

由2-氯喹啉-3-甲醛及衍生物、双甲酮和醋酸铵在温和的条件下在醋酸中生成6个收率为83％～93％的化合物3，3，6，6-四甲基-9-喹啉5-2，4，5，7，9，10-六氢化吖啶-1，8（2H，5H）-二酮衍生物，并培养成单晶。通过元素分析、IR、1HNMR、质谱和x射线单晶衍射对其结构进行了表征。测得晶体Ⅲa属单斜晶系，空间群为Peon，晶胞参数为a=2．2291（4）nm，b=1．1923（2）nm，c=1．7274（3）nm，α=β=γ=90°，Dc=1．199g／cm3。

Six novel compounds of 3,3,6,6-tetramethyl-9-quinolyl-2,4,5,7,9,10-hexahydroacridine- 1,8 （2H, 5H）-dione were synthesized through the multi-component reaction of 2-ehloroquinoline-3- earbaldehyde,dimedone and ammonium acetate in yields of 83% - 93% under mild condition, and were subsequently cultured into a single crystal. The compound was characterized by means of elemental analysis, IR, 1HNMR, MS and the crystal structure was determined by X-ray single crystal diffraction. The results show that the crystal II1 a belongs to the monoclinic system with space group Pecn,with a =2. 229 1（4） nm,b = 1. 192 3（2） nm,e = 1. 727 4（3） nm,α=β=γ=90°,Dc=1.199g/cm3 .