克拉霉素与功能性鼻内镜手术治疗慢性鼻窦炎的效果比较

Comparison on treatment effect to chronic nasosinusitis by clarithromycin (CLA) and functional nasal endoscopic surgery

目的探讨克拉霉素和鼻内镜手术治疗慢性鼻窦炎的临床疗效,为临床资料提供参考依据。方法选取2010年7月-2012年7月收治的66例慢性鼻窦炎患者,随机分为对照组和观察组各33例,对照组使用克拉霉素进行药物治疗,观察组使用鼻内镜手术治疗,观察两组患者的临床疗效,并对疗效进行主客观评价,采用SPSS18.0软件进行数据处理。结果两组患者治疗后,对照组患者总有效率96.97%明显高于观察组患者总有效率81.82%,与治疗前相比,治疗后对照组与观察组患者的视觉模拟评分法(VAS)评分差异均有统计学意义,对照组与观察组患者的Lund-Mackay评分与治疗前相比差异均有统计学意义(t=19.2263,P<0.01;t=20.4705,P<0.01);与对照组相比,观察组患者的VAS评分和Lund-Mackay评分,差异均有统计学意义(P<0.05)。结论克拉霉素药物治疗慢性鼻窦炎有较好的临床疗效、且具有无创性,费用低廉等优点,适合患者长期使用,在临床上具有重要的意义。

OBJECTIVE To investigate clinical efficacy of CLA and nasal endoscopic surgery for chronic nasosinus- itis, so as to provide reference basis for clinical data. METHODS 66 patients with chronic nasosinusitis who were hospitalized from Jul. 2010 to Jul. 2012 were randomly divided into control group and observation group, each group had 33 cases. The control group adopted drug therapy and the observation group employed nasal endoscopic surgery, then observed the clinical efficacy of each group and made objective and subjective evaluations on the effi- cacy. Relevant data were processed by SPSS 18.0 software. RESULTS After treatment, the total efficiency rate of the control group was 96.97%, which was significantly higher than that of the observation group （81.82%） ; also, the visual analogue scale （VAS） of the two groups indicated a highly significant difference after the treat- ment. In addition, the Lund-Mackay Scale of each group had a very obvious difference after treatment （t= 19.2 263,P〈0.01;t=20. 4705,P〈0.01）. The differences in VAS and Lund-Mackay Scale of both groups had statistical significance （P〈0.05）. CONCLUSION CLA produces a relatively favorable clinical efficacy in curing chronic nasosinusitis with such advantages as noninvasiveness and low price and so on. It is suitable for patients to use for a long time, and it has a significant meaning clinically.