四联疗法与序贯疗法联合益生菌治疗幽门螺杆菌感染的临床研究

Clinical comparative study of quadruple therapy versus sequential therapy combined with probiotics on Helicobacter pylori infection

目的探讨四联疗法与序贯疗法联合益生菌根除幽门螺杆菌感染临床疗效及安全性,为临床治疗提供参考依据。方法选取2010年1月-2013年4月98例幽门螺杆菌感染患者为研究对象,分成两组,分别采用四联疗法49例为A组和序贯疗法联合益生菌治疗49例为B组,比较两组临床疗效和胃肠道不良反应发生率,采用SPSS13.0软件进行分析。结果 A组总有效率为87.8%,B组总有效率为89.8%,两组比较差异无统计学意义;两组治疗后胃肠道不良反应发生率分别为46.9%和16.3%,差异有统计学意义(P<0.05)。结论序贯疗法联合益生菌根除幽门螺杆菌感染与四联疗法疗效相当,均有明显的临床效果;序贯疗法联合益生菌组胃肠道不良反应发生率更低。

OBJECTIVE To investigate the clinical effect and safety of the quadruple therapy versus the sequential therapy combined with probiotics on H. pylori infection so as to provide reference for the clinical data. METHODS From Jan 2010 to Apr 2013, a total of 98 patients with H. pylori infection were selected and divided into two groups randomly, group A and group B. group A including 49 cases received the quadruple therapy and group B including 49 cases received the sequential therapy combined with probiotics. The clinical effects and the gastrointestinal adverse reaction rates were evaluated after treatment using the SPSS13.0 software. RESULTS The total effective rate was 87.8% for group A and 89.8% for group B. The comparison of the two groups of patients had no statistical significance. The gastrointestinal adverse reaction rate after the treatment was 46. 9% and 16.3 %, respectively. The difference had statistical significance （P〈0.05）. CONCLUSION The sequential therapy combined with probiotics in the eradication of H. pylori is as effective as the quadruple therapy, with both having significant effects. And the sequential therapy combined with probiotics has lower rate of the gastrointestinal adverse reaction.