胫腓骨开放性骨折患者创口感染的病原学分析

Etiology of wound infections in patients with fractures of tibia and fibula

目的分析胫腓骨开放性骨折患者创口感染的病原学及耐药性,为创口感染的临床防治及抗菌药物使用提供理论指导。方法回顾性分析2006年1月-2013年1月医院收治的969例胫腓骨开放性骨折患者临床资料,观察其创口感染情况,分析感染率、病原菌分布及耐药性,数据采用SPSS13.0进行分析。结果 969例患者共出现124例创口感染,感染率12.8%,共分离出136株病原菌,其中革兰阳性菌76株占55.9%,革兰阴性菌60株,占44.1%;主要革兰阳性菌对万古霉素耐药性较低,主要革兰阴性菌对头孢哌酮/舒巴坦耐药性较低。结论在今后的治疗中,应做好创口感染的预防工作,规范抗菌药物的应用,以降低患者感染发生率,并使出现感染的患者得到及时、有效的处理,提高患者的生活质量。

OBJECTIVE To analyze etiology and drug resistance of wound infections in the patients with tibial open fracture, so as to provide the theory instruction for the clinical prevention and treatment of wound infection using antibiotics. METHODS To analyze etiology and drug resistance of wound infection in the patients with tibial open fracture, so as to provide the theory instruction for the clinical prevention and treatment of wound infection using antibiotics. Retrospective analysis of clinical data of 969 patients with open fractures of tibia and fibula from Jan. 2006 to Jan. 2013 was taken. The wound infection was under observation with analysis of the wound infection, infection rate, distribution and drug resistance of pathogenic bacteria. SPSS 13.0 software was used for statistical analysis. RESULTS Among 969 patients, there were 124 cases got wound infection, and the infection rate was 12.8% A total of 136 strains of pathogenic bacteria were isolated, among which 76 strains were gram positive bacteria, accounting for 55.9%, 60 strains of gram positive bacteria, accounting for 44.1%. The main gram posi- tive bacteria had low resistance to vancomycin, the resistance to cefoperazone/sulbactam in main gram negative bacteria was low. CONCLUSION In the treatment of the future, the wound infection prevention and standard application of anti bacteria drugs should be done, in order to reduce the incidence rate of infection. For improving the quality of life of patients, the treatment for patients with infection of patients should he received timely and efficiently.