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PPARs激动剂在心脑血管疾病中的研究进展 被引量:6

Research progress of PPARs agonists on cardiovascular and cerebrovascular diseases
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摘要 PPARs是一类由配体激活的转录因子,属于Ⅱ型核受体超家族成员。PPARs被激活后,能够改善胰岛素抵抗(IR)、纠正脂质代谢紊乱、逆转心肌肥厚、抑制血管平滑肌细胞(VSMCs)和内皮细胞的增殖与迁移,从而改善心脑血管的病理性重构,并具有降压效应。因此,PPARs激动剂的研究在心脑血管疾病的防治中具有重要的理论意义和临床应用价值。本文对近几年的PPARs激动剂进行综述。 PPARs are a class of ligand-activated transcription factors belonging to the nuclear receptor super- family type Ⅱ members. PPARs agonists can improve insulin resistance (IR), correct lipid metabolism disor- ders, reverse cardiac hypertrophy,inhibit VSMCs( vascular smooth muscle cells)and endothelial cell's prolife- ration and migration, and further improve cardiovascular pathological remodeling with antihypertensive effect by activating PPARs. PPARs agonists have important theoretical significance and clinical applications in treatment of cardiovascular and cerebrovascular diseases. This review summarized the progress on PPARs agonists in recent years.
出处 《中国药物化学杂志》 CAS CSCD 2014年第2期147-156,共10页 Chinese Journal of Medicinal Chemistry
关键词 过氧化物酶体增殖物激活受体 激动剂 心脑血管 peroxisome proliferator-activated receptor agonists cardiovascular
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