上皮间质转化与胆管癌

Epithelial Mesenchymal Transformation and Cholangiocarcinoma

上皮间质转化(EMT)是指上皮细胞失去原来的极性,转变为间质细胞的现象。在这个过程中,上皮细胞的标志物E-钙黏蛋白表达下调、间质细胞标志物波形蛋白表达上调,因此也称其为上皮间质转变的重要标志及特征。上皮间质转化参与了多种恶性肿瘤的生长、侵袭和转移。胆管癌是肝胆恶性肿瘤中恶性程度极高的肿瘤,其临床症状表现的较晚,大多数情况下已失去了手术的最佳治疗机会。如何认识胆管癌的发展过程,并寻找早期的预警指标,对于胆管癌患者来说EMT的发生以上皮细胞标志物的减少、间质细胞的表型增加为特征,严重影响着胆管癌患者的肿瘤进展过程及预后,对EMT的研究将有助于寻找新的抗癌靶点。

Epithelial mesenchymal transformation refers to the epithelial cells lose the original polarity ,into the phenomenon of mesenchymal cells ,in the process ,epithelial markers of E-cadherin cut ,mesenchymal cells express markers vimentin expression increases , therefore also referred to as an important symbol of epithelial mesenchymal transition and characteristics .Transformation of epithelial mesenchymal involved in a variety of malignant tumor growth ,invasion and metastasis .Bile duct carcinoma is a malignant tumor in liver malignant degree of tumor ,the clinical symptoms of late ,most cases surgery has lost the best opportunity .How to know the process of the development of the bile duct carcinoma ,and find the early warning index ,EM T for bile duct carcinoma occurred more than skin cells markers of decrease and the increases of interstitial cell phenotype characteristics , the serious influence on the tumor progression and prognosis of patients with cholangiocarcinoma ,the study of EM T will help find new anti-cancer target .