参芪扶正注射液在儿童晚期恶性实体瘤中的应用研究

Study on Efficacy of Shenqi Fuzheng Injection with Advanced Solid Tumor in Children

目的:儿童恶性实体瘤恶性程度高,预后差,研究参芪扶正注射液对儿童恶性实体瘤化疗前后辅助治疗作用。方法:2005年9月—2011年5月收集经病理确诊的儿童晚期恶性实体瘤185例(男118例,女67例)。眼外期视网膜母细胞瘤(retinoblastoma,Rb)101例,晚期肝母细胞瘤(hephatoblastoma,Hb)35例,以及IV期神经母细胞瘤(neuroblastoma,Nb)49例。随机分成研究组(参芪扶正注射液+化疗)103例以及对照组(常规化疗组)82例。分析化疗期间以及化疗后骨髓抑制、不良反应以及疗效的统计学分析。结果:(1)101例RB:随机分为研究组60例,对照组41例。研究组外周血白细胞恢复中位时间为(10.1±1.5)d,对照组为(13.4±2.3)d,统计学分析具有统计意义(X2=4.56,P=0.032);(2)35例HP:35例患儿随机分为研究组20例,对照组15例。研究组:中性粒细胞最低值、恢复时间分别为(0.6±0.05)×109/L、(15±2.2)d。对照组:中性粒细胞最低值、恢复时间分别为(0.34±0.12)×109/L、(18±1.5)d。统计学分析均有统计学意义(P<0.05)。(3)49例NB:49例患儿随机分为研究组25例,对照组24例。研究组:中性粒细胞最低值、恢复时间分别为(0.45±0.1)×109/L、(14±1.6)d;对照组:中性粒细胞最低值、恢复时间分别为(0.2±0.4)×109/L、(17±0.4)d。统计学分析均有统计学意义(P<0.05)。结论:参芪扶正注射液可明显缓解恶性实体瘤患儿化疗期间的骨髓抑制以及不良反应,具有较好扶正辅助治疗作用,具有一定的临床应用价值。

Objection ： The malignant degree of solid tumor in children is very high, and the prognosis is poor. Our study was about the clinical value of Shenqi Fuzheng Injection with solid tumor in children during chemotherapy. Method： 185 patients （male 118 ,female 67） of malignant solid tumor in children were cmfformed in our hospital in September 2005 - May 2011. 101 patients of Rb with extraocular stage,35 patients of advanced hepatoblastoma and 49 patients of neuroblas- toma of IV stage. The clinical data of study group and comparison group was studied. The study group had 103 cases, and comparison group 82 cases. The study group was treated with Shenqi Fuzheng Injection and chemotherapy and the compar- ison group only treated with chemotherapy. The level of blood white cell, recovery time of blood white cell, and side - effect of chemotherapy were analyzed. Result ： （ 1 ） 101 cases of RB ：60 cases were in the study group and 41 cases in the com- parison group. Medium recovery time of white blood cell （WBC） in study group was （10.1 ± 1.5 ） d,and （13.4 ±＋ 2.4） d in comparison group （X^2 =4.56 ,P = 0. 032）. （2） 35 cases of HB ：20 cases were in the study group and 15 cases in comparison group. The lowest number of WBC in study group was （0.6 ±0.05 ）×10^9/L, and medium recovery time of WBC in study group was （ 15 ± 2.2） d. The lowest number of WBC in comparison group was （0.34 ± 0. 12 ）×10^9/L, and medium recovery time of （WBC） in comparison group was （18 ±1.5） d （X^2 = 4.56,P = 0. 032）. （3） 49 cases of NB：25 cases were in study group, and 24 cases in comparison group. The lowest number of WBC in study group was （0.45 ±0.1 ） ×10^9/L,and medium recovery time of WBC in study group was （ 14 ± 1.6） d. The lowest number of WBC in comparison group was （0.2 ± 0.4） ×10^9/L, and medium recovery time of WBC in comparsion group was （17 ± 0.4） d （ P 〈0. 05 ）. Conclusion ： Shenqi Fuzheng Injection can increase the quality of life of advanced solid tumor in children with extrocular stage after chemotherapy, and shorten the recovery time of bone marrow suppression and relieve side effects of chemotherapy. It can be applied in the treatment of Rb with extrocular stage.