摘要
目的:通过复制不同的贫血模型,观察导黄补血丸治疗贫血的作用,为临床验方的推广及临床用药提供依据。方法:采用皮下注射乙酰苯肼复制溶血性贫血模型和腹腔注射环磷酰胺复制再生障碍性贫血模型,观察导黄补血丸对贫血小鼠红细胞、血红蛋白、红细胞压积、红细胞平均体积、平均血红蛋白量、平均血红蛋白浓度和网织红细胞的影响。结果:导黄补血丸能升高溶血性贫血小鼠的红细胞、血红蛋白、平均血红蛋白量和平均血红蛋白浓度,增大红细胞压积;对再生障碍性贫血小鼠可升高血红蛋白、平均血红蛋白量和平均血红蛋白浓度和网织红细胞数。结论:导黄补血丸对溶血性贫血和再生障碍性贫血具有一定的治疗作用。
Objective：The effect of Daohuang Buxue Pill on anemia was investigated by different models in order to popularize the prescription and provide dose basis for development of new drug. Methods ： Blood deficiency mice models were made respectively by intraperitoneal injection of CTX and subcutaneous injection of pyrodine, and the effects of Dao- huang Buxue Pill on the amounts of RBC, HGB, HCT, MCV, MCH, MCHC and reticulocyte were observed. Results ： Dao- huang Buxue Pill can increase RBC, HGB, HCT, MCV, MCH, MCHC in mice with hemolytic anemia, and also increase RBC,MCH, MCHC and reticulocyte in mice with aplastic anemia. Conclusion：Daohuang Buxue Pill has a therapeutic effect on hemolytic anemia and aplastic anemia.
出处
《中华中医药学刊》
CAS
2014年第4期839-841,I0001,共4页
Chinese Archives of Traditional Chinese Medicine
基金
江苏省高校优势学科建设项目(P09017)
