摘要
目的:探讨连续食用鲜铁皮石斛对中晚期非小细胞肺癌(NSCLC)化疗患者生活质量及无进展生存期的影响。方法:将100例中晚期NSCLC患者随机分为对照组和试验组各50例。两组均采用TP(紫杉醇+顺铂)化疗方案。试验组在对照组化疗方案基础上连续食用鲜铁皮石斛。观察患者直至出现病情进展后终止观察。于治疗前及治疗结束后1个月采用CT扫描实体瘤大小;采用欧洲癌症研究和治疗组织生命质量核心量表(EORTC QLQ-C30)评价患者生活质量;检测治疗前后血清癌胚抗原(CEA)和细胞角蛋白19片段(CYFRA-21)水平;记录治疗前后KPS评分;记录无进展生存期(PFS)。结果:治疗后试验组实体瘤疗效总有效率(CR+PR+SD)为84.0%,对照组为72.0%,两组比较差异无统计学意义(P>0.05);治疗后试验组KPS评分提高,稳定率为86.0%,优于对照组的66.0%(P<0.05);治疗后试验组生活质量评价在躯体功能、角色功能、整体生活质量、疲倦、恶心与呕吐、睡眠困难、食欲和便秘等维度方面改善优于对照组(P<0.05);治疗后试验组CEA和CYFRA-21水平低于对照组(P<0.01);试验组PFS为(7.7±1.69)个月优于对照组的(4.6±1.38)个月(P<0.01)。结论:连续食用新鲜铁皮石斛能减轻中晚期NSCLC化疗患者不良反应,提高患者的生活质量;能降低患者血清CEA和CYFRA-21水平,具有一定的抗肿瘤作用;化疗结束后继续服用,能保持病情稳定,延长无进展生存期,值得临床推广使用。
Objective:To investigate the effects of continuous consumption of fresh Dendrobium officinale on the quality of life and progression - free survival for advanced non - small cell lung cancer (NSCLC) patients with chemotherapy. Methods : 100 patients with advanced NSCLC were randomly divided into a control group and the experiment group for 50 cases in each. Both groups used TP ( paclitaxel + cisplatin) chemotherapy regimens. The experiment group were continu- ously given fresh Dendrobium officinale based on the control group. Patients were observed and treated until the progres- sion of disease. CT scan was used to dectet solid tumors's size before treatment and 1 month after treatment. The European Research and Treatment of Cancer Quality of Life Core Scale Organization ( EORTC QLQ - C30) were used to evaluate the quality of life of patients. Before and after treatment, serum carcinoembryonic antigen (CEA) and cytokeratinl9 frag- ment ( CYFRA - 21 ) levels were measured and KPS scores before and after treatment were recorded. The progression-free survival (PFS) was also recorded. Results:After treatment, the experiment group's total efficiency ( CR + PR + SD) was 84.0 % and in the control group it was 72.0%. Two groups had no statistical significance ( P 〉 0. 05 ). In experimental group after treatment, the KPS score was increased and the stability was 86.0% , better than that of 66.0% in the control group ( P 〈 0.05 ). The qualities of life after treatment in experiment group, including physical functioning , role functioning, overall quality of life , fatigue , nausea and vomiting, difficulty sleeping,loss of appetite and improving constipation and other dimensions, were better than that in control group (P 〈 0.05). In experimental group after treatment, CEA and CYFRA - 21 levels were lower than those of the control group (P 〈 0. 01 ). PFS in experiment group was (7.7 ± 1.69) months , which was better than that of the control group (4.6± 1.38) months (P 〈 0. 01 ). Conclusions : Continuous consumption of fresh Dendrobium officinale can reduce the toxicity of chemotherapy in patients with advanced NSCLC,improve the quality of life of patients. ,lower serum CEA and CYFRA- 21 and has some antitumor effect. Continuously taking after chemotherapy,thedisease can be controlled and it can prolong progression -free survival and is worthy of clinical use.
出处
《中华中医药学刊》
CAS
2014年第4期901-903,共3页
Chinese Archives of Traditional Chinese Medicine
基金
杭州市卫生科技计划重点项目(2010B062)
关键词
非小细胞肺癌
铁皮石斛
生活质量
无进展生存期
细胞角蛋白19片段
non-small cell lung cancer
Dendrobium officinale
quality of life
progression - free survival
Cytokeratin 19 fragment