连续食用鲜铁皮石斛对中晚期非小细胞肺癌化疗患者生活质量及无进展生存期的影响

Effects of Continuous Consumption of Fresh Dendrobium Officinale on Quality of Life and Progression-Free Survival for Advanced Non-Small Cell Lung Cancer Patients with Chemotherapy

目的:探讨连续食用鲜铁皮石斛对中晚期非小细胞肺癌(NSCLC)化疗患者生活质量及无进展生存期的影响。方法:将100例中晚期NSCLC患者随机分为对照组和试验组各50例。两组均采用TP(紫杉醇+顺铂)化疗方案。试验组在对照组化疗方案基础上连续食用鲜铁皮石斛。观察患者直至出现病情进展后终止观察。于治疗前及治疗结束后1个月采用CT扫描实体瘤大小;采用欧洲癌症研究和治疗组织生命质量核心量表(EORTC QLQ-C30)评价患者生活质量;检测治疗前后血清癌胚抗原(CEA)和细胞角蛋白19片段(CYFRA-21)水平;记录治疗前后KPS评分;记录无进展生存期(PFS)。结果:治疗后试验组实体瘤疗效总有效率(CR+PR+SD)为84.0%,对照组为72.0%,两组比较差异无统计学意义(P>0.05);治疗后试验组KPS评分提高,稳定率为86.0%,优于对照组的66.0%(P<0.05);治疗后试验组生活质量评价在躯体功能、角色功能、整体生活质量、疲倦、恶心与呕吐、睡眠困难、食欲和便秘等维度方面改善优于对照组(P<0.05);治疗后试验组CEA和CYFRA-21水平低于对照组(P<0.01);试验组PFS为(7.7±1.69)个月优于对照组的(4.6±1.38)个月(P<0.01)。结论:连续食用新鲜铁皮石斛能减轻中晚期NSCLC化疗患者不良反应,提高患者的生活质量;能降低患者血清CEA和CYFRA-21水平,具有一定的抗肿瘤作用;化疗结束后继续服用,能保持病情稳定,延长无进展生存期,值得临床推广使用。

Objective：To investigate the effects of continuous consumption of fresh Dendrobium officinale on the quality of life and progression - free survival for advanced non - small cell lung cancer （NSCLC） patients with chemotherapy. Methods ： 100 patients with advanced NSCLC were randomly divided into a control group and the experiment group for 50 cases in each. Both groups used TP （ paclitaxel ＋ cisplatin） chemotherapy regimens. The experiment group were continu- ously given fresh Dendrobium officinale based on the control group. Patients were observed and treated until the progres- sion of disease. CT scan was used to dectet solid tumors＇s size before treatment and 1 month after treatment. The European Research and Treatment of Cancer Quality of Life Core Scale Organization （ EORTC QLQ - C30） were used to evaluate the quality of life of patients. Before and after treatment, serum carcinoembryonic antigen （CEA） and cytokeratinl9 frag- ment （ CYFRA - 21 ） levels were measured and KPS scores before and after treatment were recorded. The progression-free survival （PFS） was also recorded. Results：After treatment, the experiment group＇s total efficiency （ CR ＋ PR ＋ SD） was 84.0 % and in the control group it was 72.0%. Two groups had no statistical significance （ P 〉 0. 05 ）. In experimental group after treatment, the KPS score was increased and the stability was 86.0% , better than that of 66.0% in the control group （ P 〈 0.05 ）. The qualities of life after treatment in experiment group, including physical functioning , role functioning, overall quality of life , fatigue , nausea and vomiting, difficulty sleeping,loss of appetite and improving constipation and other dimensions, were better than that in control group （P 〈 0.05）. In experimental group after treatment, CEA and CYFRA - 21 levels were lower than those of the control group （P 〈 0. 01 ）. PFS in experiment group was （7.7 ± 1.69） months , which was better than that of the control group （4.6± 1.38） months （P 〈 0. 01 ）. Conclusions ： Continuous consumption of fresh Dendrobium officinale can reduce the toxicity of chemotherapy in patients with advanced NSCLC,improve the quality of life of patients. ,lower serum CEA and CYFRA- 21 and has some antitumor effect. Continuously taking after chemotherapy,thedisease can be controlled and it can prolong progression -free survival and is worthy of clinical use.