平欧榛子油对高血脂大鼠的降脂作用

Effect of Flat-European Hybrid Hazelnut Oil on Hyperlipemia of Rats Induced by High Fat Diet

采用SD大鼠建立高血脂症模型并灌胃处理,通过测定模型血脂及肝脏病理变化,考察平欧榛子油辅助降血脂和预防脂肪肝的作用。结果表明:模型组的血脂水平与空白对照组差异极显著,高血脂症模型建立;大鼠灌胃结果显示,饲喂豆油及平欧榛子油低剂量、中剂量和高剂量大鼠总胆固醇(TC)的含量较高脂对照组大鼠差异显著,分别下降13%、13%、16%和16%;甘油三酯(TG)的含量较高脂对照组大鼠差异也显著,分别下降24%、24%、50%和47%;低密度脂蛋白(LDL-C)的含量较高脂对照组大鼠分别下降1%、4%、6%和26%;高密度脂蛋白(HDL-C)含量升高明显,分别升高28%、32%、41%和44%;大鼠的血糖(GLU)、丙二醛(MDA)、动脉粥样硬化指数AI1、AI2和冠心指数(R-CHR)均显著降低,并与榛子油的剂量呈现正相关;连续饲喂平欧榛子油有助于降低高血脂症大鼠肝脏脂质沉积,对大鼠肝细胞有一定的保护作用。

The hyperlipidemia model in SD rats was established and rats stomached in this manuscript.Through the determination of blood lipid and liver pathological changes in model rats,effect of Flat-European hybrid hazelnut oil on reducing blood lipid and preventing fatty liver were examined.The results showed that the levels of lipid between the model group and the control group were significantly different.The hyperlipidemia model was established.The rats gastric lavage results showed that rats fed soybean oil and Flat-European hybrid hazelnut oil low doses,middle doses and high doses total cholesterol（TC） content were significantly decreased by 13%,13%,16%and 16% compared to the high fat control group.Compared to the high fat control group rats triglyceride （TG） content were obviously different and reduced to 24%,24%,50% and 47%,respectively.Rats low density lipoprotein （LDL-C） content compared to the high fat control group were decreased by 1%,4%,6% and 26%.The rats high density lipoprotein （HDL-C） content were significantly increased 28%,32%,41% and 44%.Rats blood glucose （GLU）,malonaldehyde （MDA）,atherosclerosis index AI1,AI2 and coronary index （R-CHR） were significantly decreased and showed a positive correlation with hazelnut oil dose.Continuous feeding Flat-European hybrid hazelnut oil helped to reduce lipid deposition in liver in hyperlipidemia rats,had certain protective effect on rat liver cells.