血清高迁移率族蛋白 B1和糖类抗原72-4在早期胃癌患者检测中的价值

The value of serum HMGB1 and CA72-4 in patients with early gastric cancer

目的：探讨血清高迁移率族蛋白B1（HMGB1）和糖类抗原72-4（CA72-4）在早期胃癌患者检测中的价值。方法50例早期胃癌患者作为胃癌组，45例胃部良性病变患者作为胃部良性病变组，100例健康查体者作为健康组，测定并比较入选人群血清HMGB1和CA72-4。结果早期胃癌组血清HMGB1和CA72-4阳性率高于胃部良性病变组和健康体检组（χ^2＝33．69、82．95、51．41、104．74，均P＜0．01），而胃部良性病变组的阳性率与健康体检组的差异无统计学意义（χ^2＝3．80、1．90，均P＞0．05）。 HMGB1诊断早期胃癌敏感度为70．0％，特异度为95．2％，准确度为88．7％；CA72-4诊断早期胃癌的敏感度为80．0％（40／50），特异度为97．2％（141／145），准确度为92．8％（181／195）。联合检测时，诊断早期胃癌的敏感度为94．0％（47／50），而特异度为93．1％（135／145），准确度为93．3％（182／195），高于单项检测的敏感度与准确度。有淋巴结转移的早期胃癌患者血清HMGB1和CA72-4均明显高于无淋巴结转移的患者（ t＝2．927、4．096，均P ＜0．05）。结论联合检测血清HMGB1和CA72-4可以早期诊断胃癌，并对患者预后进行判断。

Objective To study the value of serum HMGB1（high mobility group box-1） and carbohydrate antigen 72-4（CA72-4） in patients with early gastric cancer .Methods 50 cases of early gastric cancer patients were＆amp;nbsp;enrolled as a group ,45 cases of gastric lesions as benign gastric benign group ,100 cases of healthy people as healthy group.Serum HMGB1 and CA72-4 in all people were detected .Results Early gastric cancer serum HMGB1 and CA72-4 was higher than benign lesions in the stomach and the healthy group （χ2 =33.69,82.95,51.41,104.74, P＆lt;0.01）,while benign lesions of the stomach and the positive rate healthy group ,the difference was not statistically significant（χ2 =3.80,1.90,all P＆gt;0.05）.HMGB1 diagnosis of early gastric cancer sensitivity was 70.0%,specific-ity 95.2%and accuracy was 88.7%.CA72-4 diagnosis of early gastric cancer with a sensitivity of 80.0%（40/50）, specificity was 97.2%（141/145） an accuracy of 92.8%（181/195）.Joint detection,diagnosis of early gastric cancer with a sensitivity of 94.0%（47/50）,while the specificity was 93.1%（135/145）,the accuracy was 93.3%（182/195）,higher than those of the single detection sensitivity and accuracy .Early gastric cancer with lymph node metasta-sis in patients with serum HMGB1 and CA72-4 were significantly higher than those in patients without lymph node metastasis,the two groups were significantly different （t=2.927,4.096,all P＆lt;0.05）.Conclusion Joint detection of serum HMGB1 and CA72-4 allows early diagnosis of gastric cancer ,and to determine the prognosis of patients .