甘肃省庄浪县660例药品不良反应报告分析

Analysis of 660Reports of Adverse Drug Reactions in Zhuanglang County of Gansu Province

目的分析研究庄浪县药物不良反应情况,为临床合理用药提供参考。方法收集我县2010年1月至2012年10月上报国家药物不良反应监测中心的660例药品不良反应(ADR)报告,从患者年龄、性别、病史、给药途径、药物品种及临床表现等方面进行统计分析。结果 660例ADR涉及药物425个品种、238个厂家;引起ADR的主要品种为抗菌素,共289例,占总发生例数的43.79%;ADR临床表现主要为消化系统的损害,其次是皮肤损害。结论我县抗菌素滥用问题依然存在,民众医药知识贫乏,自我保护意识淡薄。需加强我县抗菌素药物使用管理,加大宣教卫生保健和药物使用知识的力度,提高临床合理用药水平。

Objective To investigate the situation of adverse drug reactions （ADRs） in Zhuanglang County, so as to provide a reference for clinical rational drug use. Methods A total of 660 cases of ADRs reported to the National Adverse Drug Reaction Monitoring Center from January 2010 to October 2012 in our county were collected. A retrospective method was used to conduct the statistical analysis on aspects of patientslage, sex, medical history, route of administration, drug varieties, and clinical manifestations, etc. Results The 660 ADR cases involved 425 varieties of drugs, 238 manufacturers. The main variety of drug causing ADRs was antibiotics with a total of 289 cases, accounting for 43.79% of the total ADR cases. The main clinical manifestation of ADR was digestive system damage, followed by skin lesions. Conclusion Antibiotic abuse still persists in our county. The public have poor medical knowledge and weak self-protection consciousness. The antibiotic use management should be strengthened, the level of rational drug use needs to be improved and knowledge of health care and drug use should widely spread.