我国淫羊藿药材主要活性成分变异分析

Study on Variation of the Main Active Components in Chinese Epimedium Drugs and their Standardization

对我国部分市售淫羊藿药材的主要活性成分进行抽样检测证明：不同地区淫羊藿药材成分含量差异极显著，淫羊藿苷、朝藿定A、B、C四种成分总含量在1．49％～6．96％之间，总黄酮变异在4．15％～9．66％之间．部分药材四种黄酮总含量和总黄酮含量低于药典标准．在不同地区采集的药典规定的五种淫羊藿药材在成分组成和含量方面差异极显著，四种黄酮总含量变异在2．08％～5．38％之间；以巫山淫羊藿为例，不同产地和同一产地的巫山淫羊藿药材个体间在四种黄酮组成上有明显差异，在四种黄酮总含量和总黄酮含量上差异极显著．因此，淫羊藿药材标准化应该从以下几个方面研究：①对野生资源进行系统地调查和评估，筛选活性成分相关的优良遗传资源；②进行种质改良，培育优良新品种，推进中药材品种标准化；③研究适宜的栽培条件和栽培技术，为GAP基地建设和中药质量标准化提供物质基础和技术基础．

There are very significant differences on the main active components among Epimedium Drugs from different markets.The total contents of Icariin and Epimedin A , B and C varied from 1.49%to 6. 96%.Some of them are under the standard of China pharmacopoeia .Very significant differences also exist among the Epimedium Drugs of five species stated by China pharmacopoeia .The total contents of Icariin and Epimedin A , B and C varied from 2.08%to 5.38%;within the species of Epimedium wushanense, there exist variations on contents of the main active components and constitute of Icariin and Epimedin A , B and C between different plants from different areas .So the method for standardization of Epimedium Drugs should be：①systematic investigation on the wild Epimedium resources and screening of excellent germ plasms based on the main active components;②breeding research based on the systematic resource investigation for variety standardization;③GAP research for drug standardization .