介孔材料固定化酶的研究进展及其应用前景

Research Progress and Application Prospect of Enzyme Immobilization on Mesoporous Silica-Based Materials

评述了介孔材料固定化酶的研究新进展,重点分析了酶分子被固载到介孔材料的纳米孔中后,载体孔径尺寸和纳米孔微环境对固定化酶催化活性及其稳定性可能产生的影响。同时,以水解酶和氧化还原酶为例,对介孔材料固定化酶在生物柴油制备、生物质转化、手性药物及精细化学品合成、生物燃料电池及生物传感器制备等领域的应用前景进行了展望。

This paper reviewed the current status of the development of enzyme immobilization on mesoporous silica-based materials,in particular with focus on the main factors（pore diameter and nanopore microenvironment） influencing the catalytic properties of enzymes immobilized in nanopores of mesoporous supports.The application prospect of the immobilized enzymes in biodiesel production,biomass conversion,synthesis of fine chemicals and chiral pharmaceuticals,fabrication of biofuel cells and biosensors was also discussed using hydrolase and oxidoreductase as model enzymes.