久坐行为与代谢综合征关系的Meta分析

The association between sedentary behavior and metabolic syndrome:a meta analysis

目的探讨研究久坐行为与代谢综合征之间的关系。方法计算机检索PubMed，Embase，the Cochrane Library、CNKI、维普、万方数据库，检索截至2013年10月。依据MOOSE、QATSO和STROBE进行质量评价，采用Statal2．0进行数据统计分析。结果初步检索出文献631条，最终纳入10篇有关久坐行为与代谢综合征关系的研究，总共包括21393例观察对象。其中1项研究为高质量研究、7项为中级质量研究、2项为低质量研究。久坐行为时间较长会增加代谢综合征的发病率73％（P〈0．01）；亚组分析提示，女性患代谢综合征的风险较高（女：OR2．07，CI1．70～2．52；男：OR：1．54，CI1．28～1．85），但男女人群之间并无统计学差异（P〉0．05）。结论久坐行为持续时间增加可导致代谢综合征发病率升高，控制久坐时间可以降低代谢综合征的发病风险。

Objective To quantify the relationship of sedentary behavior and metabolic syndrome. Methods The websites of PubMed, Embase, Cochrane Library, CNKI, VIP, and Wanfang database were searched （up to October 2013）. Quality of articles was evaluated based on MOOSE, QATSO and STROBE, and statistical analyses were performed using Stata12.0 software. Results Total- ly, 631 articles were yielded from the search, of which 10 were eligible, including 21 393 participants. One article was classified as high quality, 7 articles were classified as moderate quality and 2 articles as low quality studies. The results of meta-analysis showed that： greater time spent sedentary increased the odds of metabolic syndrome by 73 %（P〈0.01）. Sub meta analysis indicated that female might have higher risk of metabolic syndrome（female：OR 2.07, CI 1.70--2.52 vs. male：OR 1.54, CI 1.28--1.85） ,but with no significant statistical difference （P〉0.05）. Conclusion People who spend higher amounts of time in sedentary behaviours have greater odds of having metabolic syndrome. Reducing sedentary behaviours is potentially important for the prevention of metabolic syndrome.