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术后肠梗阻动物模型的建立 被引量:2

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摘要 术后肠梗阻(POI)是指术后无机械性梗阻的前提下,因肠蠕动障碍或肠动力缺乏导致的肠梗阻^[1]。POI使患者术后住院时间明显延长,是阻碍术后康复的主要因素,给患者家庭和社会带来了沉重的经济负担。本研究旨在通过观察不同手术创伤对大鼠POI的影响,建立一种能真实模拟临床腹部大手术的POI动物模型。
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2014年第4期914-914,共1页 Chinese Journal of Experimental Surgery
基金 浙江省卫生厅支撑学科项目,浙江省自然科学基金资助项目
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  • 1Mattei P, Rombeau JL. Review of the patho- physiology and management of postoperative ileus[ J ]. World J Surg,2006,30 ( 8 ) : 1382- 1391.
  • 2Miller MS, Galligan JJ, Burks TF. Accurate measurement of intestinal transit in the rat [ J]. J Pharmacol Methods, 1981,6 ( 3 ) : 211-217.
  • 3Kalff JC, Schraut WH,Simmons RL, et al. Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileus [ J ]. Ann Surg, 1998,228 ( 5 ) :652-663.
  • 4Shaw M, Pediconi C, McVcy D, et al. Safe- ty and efficacy of ulmorelin administered postoperatively to accelerate recovery of gastrointestinal raotility following partial bowel resection :results of two randomized, placebo-controlled phase 3 trials [ J]- Dis Colon Rectum,2013,56(7) :888-897.
  • 5Yu CS, Chun HK,Stambler N,et al. Safety and efficacy of methylnaltrexone in short- ening the duration of postoperative ileus following segmental colectomy: results of two randomized, placebo-controlled phase 3 trials [ J ]. Dis Colon Rectum, 2011,54 (5) :570-578.
  • 6Popescu I, Fleshner PR, Pezzullo JC, et al. The Ghrelin agonist TZP-101 for manage- ment of postoperative ileus after partial co- lectomy : a randomized, dose-ranging, pla- cebo-controlled clinical trial [ J ]. Dis Colon Rectum, 2010,53 ( 2 ) : 126-134.
  • 7Fraser GL, Venkova K, Hoveyda HR, et . Effect of the ghlin receptor agonist TZP- 101 on colonic transit in a rat model of txJst- operative ileus [ J ]. Eur J Pharmacol, 2009, 604(1-3) :132-137.
  • 8Kitazawa T, De Smet B, Verbeke K, et al. Gastric motor effeets of peptide and non- peptide ghrelin agonists in mice in vivo and in vitro [ J ]. Gut, 2005, 54 ( 8 ) : 1078- 1084.
  • 9Trudel L, Tomasetto C, Rio MC, el al. Gh- relin/motilin-related peptide is a potent prokinetie to reverse gastric postoperative iteus in rat [ J ]. Am J Physiol Gastrointest Liver Physlol,2002,282(6) ..G948-G952.

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