窄谱中波紫外光联合复方甘草酸苷胶囊及复方氟米松软膏治疗玫瑰糠疹临床疗效观察

Clinical efficacy study of narrow band ultraviolet B combined with compound glycyrrhizin cap- sules and compound flumetasone ointment in treatment of pityriasis rosea

目的评价窄谱中波紫外光联合复方甘草酸苷胶囊、复方氟米松软膏治疗玫瑰糠疹疗效。方法将74例患者随机分为两组，治疗组38例采用窄谱中波紫外光联合复方甘草酸苷胶囊、复方氟米松软膏治疗，对照组36例采用窄谱中波紫外光联合复方甘草酸苷胶囊，疗程均为3周。于治疗前及治疗1、2、3周后分别对症状、体征进行客观评分；治疗结束后观察疗效，并记录不良反应。结果治疗3周后，治疗组症状体征积分为0．82±1．63，低于对照组（2．02±1．58），差异有统计学意义（P〈0．05）；治疗组有效率（94．7％）高于对照组（88．9％），差异有统计学意义（P〈0．05）。两组均未见明显不良反应。结论窄谱中波紫外光联合复方甘草酸苷胶囊、复方氟米松软膏治疗玫瑰糠疹疗效好，安全性高。

Objective To evaluate the efficacy of narrow band ultraviolet B （NB-UVB） irradia- tion combined with compound glycyrrbizin capsules and compound flumetasone ointment on pityriasis rosea. Methods Seventy-four patients with pityriasis rosea were randomly divided into two groups, 38 patients in trrial group were treated with narrow band ultraviolet B irradiation combined with compound glycyrrhizin capsules and compound flumetasone ointment, and 36 patients in control group were treated with narrow band ultraviolet B irradiation combined compound glycyrrhizin capsule,. The treatment course was 3weeks for both groups. Symptoms and physical signs were objectively scored between the two groups before and 1, 2, 3 weeks after treatment. The curative effect and adverse reactions were recorded at the end of treatment. Results After 3weeks, integral of symptoms and signs in the treatment group was 0. 82 ± 1.63, and it was 2. 02 ± 1.58 in control group, there was significant difference in efficacy be- tween the two groups （ P 〈 0. 05 ）. The effective rate in the treatment group and the control group was re- spectively 94.7% and 88.9%, there was significant difference in efficacy between the two groups（P 〈 0.05 ）. There were no obvious adverse reaction in the two groups. Conclusions Narrow band ultraviolet B irradiation combined with compound glycyrrhizin capsules and compound flumetasone ointment is an ef- fective and safe method in the treatment of pityriasis rosea.