期刊文献+

西妥昔单抗治疗结直肠癌的分子预测标志研究现状 被引量:3

原文传递
导出
摘要 结直肠癌是三大最常见的恶性肿瘤之一,且在消化道恶性肿瘤中具有最高的病死率。西妥昔单抗、帕尼单抗等靶向药物在KRAS基因野生型患者治疗中的应用,起到了显著的临床效果,但是仍有相当数量的患者对西妥昔单抗的治疗无效,为避免患者经济上的损失及药物资源的浪费,亟需更加精确、特异的单抗疗效预测因子应用于临床。
出处 《中国实用医刊》 2014年第9期103-105,共3页 Chinese Journal of Practical Medicine
  • 相关文献

参考文献3

二级参考文献62

  • 1Nordlinger B, Guiguet M, Vaillant JC,et al. Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Fran~aise de Chirurgie. Cancer, 1996,77 (7) :1254- 1262.
  • 2Karapetis CS, Khambata-Ford S, Jonker D J, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med, 2008, 359 ( 17 ) : 1757-1765.
  • 3Amado RG, Wolf M, Peeters M, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic: colorectal cancer. J Clin Oncol, 2008, 26 (10) : 1626-1634.
  • 4Peeters M, Price TJ, Cervantes A, et al. Randomized phase IH study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer. J Clin Oncol, 2010, 28(51 ) :4706-4713.
  • 5Bokemeyer C, Bondarenko I, Hartmann JT, et al. Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first- line treatment for metastatic colorectal cancer: the OPUS study. Ann Oncol, 2011, 22(7) :1535-1546.
  • 6NCCN. Clinical practice guidelines in oncology: colon cancer. Version 3. 2012 [ EB/OL]. [ 2012-07-16 ]. http://www, necn. org/professionals/physician_gls/pdf/colon, pdf.
  • 7Der C J, Cooper GM. Altered gene products are associated with activation of cellular Kras genes in human lung and colon carcinomas. Cell, 1983, 32( 1 ) :201-208.
  • 8Gideon P, John J, Frech M, et al. Mutational and kinetic: analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity. Mol Cell Biol, 1992,12 (5) :2050-2056.
  • 9Rajagopalan H, Bardelli A, Lengauer C, et al. Tumorigenesis : RAF/RAS oncogenes and mismatch-repair status. Nature, 2002, 418(6901 ) :934.
  • 10Samowitz WS, Curtin K, Schaffer D,et al. Relationship of K-ras mutations in colon cancers to tumor location, stage, and survival: a population-based study. Cancer Epidemiol Biomarkers Prey, 2000,9( 11 ) :1193-1197.

共引文献63

同被引文献30

引证文献3

二级引证文献15

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部