摘要
目的:探讨贵州省人群原发性肝癌(PHC)常见的危险因素。方法采用成组病例对照研究,通过非条件Logistic回归分析及分层分析,对贵州省人群PHC常见的危险因素,以及饮酒合并乙型肝炎病毒感染与PHC发生的关系进行分析。结果饮酒(OR=2.948,95%CI2.096~4.146,P=0.000)、5年前经济状况(OR=0.386,95%CI0.279~0.534,P=0.000)、肝癌家族史(OR=2.402,95%CI1.372~4.206,P=0.002)、吸烟(OR=3.468,95%CI2.265~5.311,P=0.000)、慢性肝病史(OR=1.502,95%CI1.054~2.141,P=0.024)、乙型肝炎病毒感染(OR=31.999,95%CI19.318~53.002,P=0.000)、糖尿病史(OR=4.750,95%CI2.761~8.171,P=0.000)在病例组和对照组间的差异有统计学意义;饮酒合并乙型肝炎病毒感染者OR值达96.903(95%CI35.265~266.275,P=0.000)。结论乙型肝炎病毒感染仍为贵州省人群PHC常见的危险因素,而饮酒可增加乙型肝炎病毒感染者患PHC的风险。
Objective To investigate the common risk factors of primary hepatocellular cancer (PHC) in Guizhou province . Methods The group case-control study was adopted .The main related-factors of primary PHC in Guizhou provincial population and the relation between drinking combined hepatitis B viral infection with the PHC occurrence were analyzed by the unconditional Logistic regression analysis and the stratification analysis .Results Drinking(OR=2 .948 ,95% CI 2 .096-4 .146 ,P=0 .000) ,eco-nomic status 5 years ago(OR=0 .386 ,95% CI 0 .279 -0 .534 ,P= 0 .000) ,family history of PHC(OR= 2 .402 ,95% CI 1 .372 -4 .206 ,P=0 .002) ,cigarette smoking (OR=3 .468 ,95% CI 2 .265 -5 .311 ,P=0 .000) ,chronic liver disease(OR= 1 .502 ,95% CI 1 .054-2 .141 ,P=0 .024) ,HBV infection(OR=31 .999 ,95% CI 19 .318 -53 .002 ,P=0 .000) and diabetes mellitus(OR=4 .750 , 95% CI 2 .761-8 .171 ,P=0 .000) ,the differences between the patients group and the control group had statistical significance ;the OR value of drinking combined with HBV infection was 96 .903(95% CI 35 .265-266 .275 ,P=0 .000) .Conclusion HBV infection is still the common risk factor of PHC in Guizhou provincial population .Drinking can increase the risk in the individuals infected with HBV .
出处
《重庆医学》
CAS
CSCD
北大核心
2014年第10期1157-1160,共4页
Chongqing medicine
基金
国家重点基础研究发展计划(973)专项课题资助项目(2011CB512114)
贵州省科技计划课题资助项目[黔科合SZ(2011)3001]
关键词
肝肿瘤
病例对照研究
肝炎
乙型
饮酒
liver neoplasms
case-control studies
hepatitis B
alcohol drinking