贵州省原发性肝癌危险因素的病例对照研究

A case-control study on risk factors of primary hepatocellular cancer in Guizhou

目的：探讨贵州省人群原发性肝癌（PHC）常见的危险因素。方法采用成组病例对照研究，通过非条件Logistic回归分析及分层分析，对贵州省人群PHC常见的危险因素，以及饮酒合并乙型肝炎病毒感染与PHC发生的关系进行分析。结果饮酒（OR＝2．948，95％CI2．096～4．146，P＝0．000）、5年前经济状况（OR＝0．386，95％CI0．279～0．534，P＝0．000）、肝癌家族史（OR＝2．402，95％CI1．372～4．206，P＝0．002）、吸烟（OR＝3．468，95％CI2．265～5．311，P＝0．000）、慢性肝病史（OR＝1．502，95％CI1．054～2．141，P＝0．024）、乙型肝炎病毒感染（OR＝31．999，95％CI19．318～53．002，P＝0．000）、糖尿病史（OR＝4．750，95％CI2．761～8．171，P＝0．000）在病例组和对照组间的差异有统计学意义；饮酒合并乙型肝炎病毒感染者OR值达96．903（95％CI35．265～266．275，P＝0．000）。结论乙型肝炎病毒感染仍为贵州省人群PHC常见的危险因素，而饮酒可增加乙型肝炎病毒感染者患PHC的风险。

Objective To investigate the common risk factors of primary hepatocellular cancer （PHC） in Guizhou province . Methods The group case-control study was adopted .The main related-factors of primary PHC in Guizhou provincial population and the relation between drinking combined hepatitis B viral infection with the PHC occurrence were analyzed by the unconditional Logistic regression analysis and the stratification analysis .Results Drinking（OR=2 .948 ,95% CI 2 .096-4 .146 ,P=0 .000） ,eco-nomic status 5 years ago（OR=0 .386 ,95% CI 0 .279 -0 .534 ,P= 0 .000） ,family history of PHC（OR= 2 .402 ,95% CI 1 .372 -4 .206 ,P=0 .002） ,cigarette smoking （OR=3 .468 ,95% CI 2 .265 -5 .311 ,P=0 .000） ,chronic liver disease（OR= 1 .502 ,95% CI 1 .054-2 .141 ,P=0 .024） ,HBV infection（OR=31 .999 ,95% CI 19 .318 -53 .002 ,P=0 .000） and diabetes mellitus（OR=4 .750 , 95% CI 2 .761-8 .171 ,P=0 .000） ,the differences between the patients group and the control group had statistical significance ;the OR value of drinking combined with HBV infection was 96 .903（95% CI 35 .265-266 .275 ,P=0 .000） .Conclusion HBV infection is still the common risk factor of PHC in Guizhou provincial population .Drinking can increase the risk in the individuals infected with HBV .