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重组腺病毒载体靶向性策略的研究进展 被引量：3

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摘要 近年来，研究者致力于突破基因治疗的瓶颈，极大推动了基因治疗的发展。载体系统是基因治疗的基础，截止2013年7月，在“Gene Therapy Clinical Trial Worldwide”网站登记注册的基因治疗方案中，重组腺病毒载体占476项（23.5%）。在6个亚群（A-F）、50多种血清型的腺病毒载体中，5型腺病毒（adenovirus type 5，Ad5）可特异性识别并结合多种正常组织高表达的柯萨奇病毒-腺病毒受体（coxsackie-adenovirus receptor，CAR）从而进入细胞发挥作用，基因转导效率高，因此，Ad5是目前应用最广泛的腺病毒载体。
作者 薛淑雅 杨月峰
机构地区 安徽医科大学研究生院 军事医学科学院放射与辐射医学研究所实验血液学研究室
出处 《中国医药生物技术》 2014年第2期129-132,共4页 Chinese Medicinal Biotechnology
基金 国家高技术发展研究计划(863计划)(2012AA020807) 国家自然科学基金(30901379)
关键词 重组腺病毒载体 靶向性策略 柯萨奇病毒-腺病毒受体 RECEPTOR 基因治疗 基因转导效率 特异性识别 载体系统
分类号 R346 [医药卫生—基础医学]
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参考文献38

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二级参考文献75

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共引文献35

同被引文献28

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引证文献3

二级引证文献6

中国医药生物技术
2014年 第2期

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