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内皮型一氧化氮合酶脱偶联在心血管疾病中的致病作用 被引量：14

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摘要 二聚体结构的内皮型一氧化氮合酶(eNOS)氧化L-精氨酸生成一氧化氮(NO),后者对心血管系统具有保护作用。血管内氧化还原反应失衡导致eNOS脱偶联,脱偶联的eNOS产生超氧化物而非NO,导致内皮功能损伤,进而引起多种心血管疾病的发生和进展。深入了解eNOS脱偶联与心血管疾病的关系,对预防和治疗心血管疾病具有重要意义。
作者 赵艳霞 格日力
机构地区 青海大学医学院
出处 《中国循环杂志》 CSCD 北大核心 2014年第4期315-318,共4页 Chinese Circulation Journal
基金 国家自然科学基金资助项目(No.31160219) 国家国际合作项目(No.2011DFA32720) 国家973计划项目(No.2012CB518200)
关键词 内皮型一氧化氮合酶 脱偶联 心血管疾病 一氧化氮
分类号 R54 [医药卫生—心血管疾病]
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参考文献32

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二级参考文献19

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共引文献7

同被引文献185

引证文献14

二级引证文献103

中国循环杂志
2014年 第4期

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