晚期肺癌125I粒子植入治疗近期疗效观察

Short-term efficacy of 125I seeds implantation in the treatment of advanced lung cancer

目的 观察CT引导下经皮肺穿刺植入125I粒子治疗晚期肺癌的近期疗效.方法 20例晚期肺癌患者在CT引导下经皮肺穿刺肺癌组织间植入125I粒子,通过影像学手段观察近期疗效,并观察临床不良反应.结果 复查20例植入粒子后3个月以上患者的CT影像,其中,完全缓解15％（3/20）、部分缓解55％（11/20）、无变化30％ （6/20）,总有效率为70％,并发气胸15％（3/20）、咳少量血痰20％（4/20）.随访时间3～18个月,1例术后5个月死于呼吸衰竭.结论 125I粒子植入治疗晚期肺癌并发症少,近期疗效满意,远期疗效待观察.

Objective To observe the short-term efficacy of percutaneous lung puncture implantation of 125I seeds guided by CT in the treatment of advanced lung cancer.Methods Percutaneous lung puncture implantation of 125I seeds were performed in 20 cases of advanced lung cancer patients.The shortterm efficacy was observed according to the imaging results,and the complications were also followed.Results According to the CT images,15％ （3/20） were complete remission in 20 cases implanted 125I seeds for more than 3 months,and 55％ （11/20） were partial remission,30％ （6/20） were no remission,15％ （3/20） were concurrent pneumothorax,20％ （4/20） coughed a few bloody sputum.The total effective rate was 70％.The follow-up time ranged from 3 to 18 months.1 case died of respiratory failure 5 months after surgery.Conclusion Implantation of 125I seeds in the treatment of advanced lung cancer showed few complications and a satisfactory short-term efficacy,while the long-term efficacy was to be observed.