转化医学模式下疾病标志物的挖掘

The mining of the disease markers in translational medicine research

疾病标志物是用于疾病的鉴定、早期诊断及预防、治疗过程中的监控。疾病标志物的挖掘包括发现、验证、确认与应用四大核心环节,寻找和发现有价值的疾病标志物已经成为目前研究的一个重要热点。传统的疾病标志物发展途径已渐渐满足不了当今研究的需要,而填补这一从实验室到临床的鸿沟要依靠转化医学模式的发展成果,即转化医学模式下的疾病标志物挖掘方式才是最适用的。本文介绍了国内外一些转化医学在疾病标志物发现与验证确认过程中方法策略的运用,如与标志物发现紧密相关的分子分析、成像技术等,转化医学分析方法中的生物分析验证和临床验证阶段,从而进一步指出与转化医学相结合的疾病标志物的挖掘能够更好地解决标志物实验室发现与临床应用之间过渡研究的难题。

Disease markers are defined to identify, early diagnose and monitor in the prevention and treatment of disease. The mining of the disease markers includes four steps which are discovery, validation, confirmation and application. To seek and discover the valuable disease markers has been a hotspot in this field nowadays. The traditional way of disease markers development has been not gradually satisfy the need of the research, and the development of the translational medicine can fill the gap from bench to bedside, namely, the mining of the disease markers in translational medicine research is the most suitable as a solution. In this paper some methods and strategies of translational medicine are introduced, which are applied in the process of discovery, validation and confirmation of disease markers at home and abroad, such as molecular analysis and imaging techniques closely related to the discovery of markers, biological analysis validation and clinical validation phase in the translational medicine analysis methods. Thus it is further pointed out that the combination between translational medicine and the mining of disease markers could solve the problem of the transition between markers laboratory findings and clinical application research.