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基于钌多吡啶类配合物的DNA分子光开关及生物传感研究 被引量：1

DNA molecular light switch and biosensors based on ruthenium(Ⅱ) polypyridyl complexes
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摘要 DNA结构具有多态性,利用小分子化合物对不同结构的DNA分子进行识别及调控具有重要的生物学意义.本文主要针对近年来钌多吡啶配合物作为DNA分子光开关的研究进行综述,内容包括DNA分子光开关的机制,不同结构DNA的分子光开关,DNA分子光开关的开关循环控制策略和钌多吡啶类配合物及与纳米材料相结合作为生物传感器的研究. There is a great interest in the development of small molecules that can target and regulate DNA. In this review, we summarize the recent development of DNA molecular light switch based on ruthenium（II） polypyridyl complexes, which include the principle of DNA molecular light switch, light switch of different DNA conformations as well as the methods of cycling the switch. The application of ruthenium（II） polypyridyl complexes for label-free DNA-based sensing is highlighted too.
作者 石硕 姚天明 计亮年
机构地区 同济大学化学系 生物无机与合成化学教育部重点实验室 中山大学化学与化学工程学院
出处 《中国科学：化学》 CAS CSCD 北大核心 2014年第4期460-470,共11页 SCIENTIA SINICA Chimica
基金 国家自然科学基金(20901060 31170776 81171646) 中央高校基本科研业务费的资助
关键词 钌多吡啶配合物 DNA 分子光开关 生物传感 ruthenium（II） polypyridyl complex, DNA, molecular light switch, DNA biosensor
分类号 O627.8 [理学—有机化学]
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参考文献60

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同被引文献21

  • 1Amouyal Edmond, Homsi Abdulrazzak, Chambron Jean- Claude, et al. Synthesis and study of a mixed-ligand ruthe- nium(11) complex in its ground and excited states :bis( 2, 2 '-bipyridine ) ( dipyrido [ 3,2-a : 2',3 '-c ] phenazine-N 4 N 5)ruthenium(11) [J]. J Chem Soe Dalton Trans , 1990, (6) :1841-1845.
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  • 3Carter Michael T, Rodriguez Marisol, Bard Allen J. Volta- mmetric studies of the interaction of metal chelates with DNA. 2. Tris-chelated complexes of cobalt (III) and iron (11) with 1,10-phenanthroline and 2,2'-bipyridine [ J ]. J Am Chem Soc, 1989,111 (24) : 8901-8911.
  • 4Dupureur Cynthia M, Barton Jacqueline K. Structural stud- ies of A-and A-[Ru (phen) 2dppz] 2+bound to d ( GTCGAC ) 2 : characterization of enantioselective interca- lation[J]. Inorg Chem, 1997,36( 1 ) :33-43.
  • 5Zeglis Brian M, Pierre Valerie C, Barton Jacqueline K. Metallo-intercalators and metallo-insertors [ J ]. Chem Commun,2007, (44) :4565-4579.
  • 6McConnell Anna J,Lim Mi Hee, Olmon Eric D, et al. Lu- minescent properties of Ruthenium (11)complexes with sterically expansive ligands bound to DNA defects[ J]. In- org Chem,2012,51 (22) : 12511-12520.
  • 7Hu Lianzhe, Bian Zheng, Li Haijuan, et al. [ Ru (bpy) 2dppz]2+electrochemiluminescence switch and its appli- cations for DNA interaction study and label-free ATP aptasensor [ J]. Anal Chem ,2009,81 (23) :9807-9811.
  • 8Pittman Tommie Lyndon, Miao Wujian. Examination of e- lectron transfer through DNA using electrogenerated chem- iluminescence [ J ]. J Phys Chem C, 2008, 112 ( 43 ) : 16999-17004.
  • 9Lu Liping, Xu Laihui, Kang Tianfang, et al. Investigation of DNA damage treated with perfluorooctane sulfonate (PFOS) on ZrO 2/DDAB active nano-order film [J]. Bio- sens Bioelectron,2012,35( 1 ) :180-185.
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中国科学：化学
2014年 第4期

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