刺山柑软膏抗炎止痒作用评价

The anti-inflammatory and antipruritic effects of capparis spinosa L ointment

目的:评价刺山柑软膏的抗炎、止痒作用。方法:昆明小鼠50只,随机分为基质组(10只)、丙酸氯倍他索组(10只)、刺山柑软膏组(低、中剂量各10只),通过对二甲苯致鼠耳肿胀和冰醋酸致小鼠腹腔毛细血管通透性增高的影响评价刺山柑软膏抗炎作用。通过对右旋糖酐致小鼠全身瘙痒的影响评价刺山柑软膏止痒作用。结果:刺山柑乳膏可抑制鼠耳肿胀和腹腔毛细血管通透性增高.减轻小鼠全身瘙痒,且呈剂量依赖性。结论:刺山柑软膏具有抗炎、止痒作用。

Objective： To evaluate the anti-inflammatory and anti-pruritic effects of capparis spinosa L ointment. Methods： Fifty Kunming mice were divided into blank base group （ 10 mice）, clobetasol propionate group （ 10 mice） and apparis spinosa L ointment group （low, middle and high dose, 10 mice, respectively）. The anti-inflammatory effect was evaluated by reducing the xylene-induced ears swelling and glacial acetic acid-induced abdominal capillary permeability. The effect of anti-pruritic was evaluated by relieving dextran- induced itching. Results： Capparis spinosa L ointment inhibited mice ears swelling, abdominal capillary per- meability and itching in a dose-dependent manner. Conclusion： Capparis spinosa L ointment has anti-inflam- matory and anti-pruritic effects.