血管内皮细胞生长因子在口腔鳞状细胞癌进展和预后中的作用研究进展

Research progress of vascular endothelial growth factor in progression and prognosis of oral squamous cell carcinoma

血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)是目前被鉴定出的最强的血管生长因子,其家族由7个配体、3种受体以及2种共受体组成。通过多条信号通路,VEGF表现出促进血管内皮细胞增殖和新生血管形成、淋巴内皮细胞生长和淋巴道转移、抗凋亡等多种细胞学效应。肿瘤的生长、转移及预后与VEGF密切相关,新生血管既为肿瘤生长提供营养,也为肿瘤的转移提供通道。本文针对VEGF及其受体的分子结构、信号机制、细胞学效应,以及其与口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)进展和预后的关系等进行综述。

Vascular endothelial growth factor （VEGF） has proven to be the most critical angiogenic factor identified to dates, whose family members are composed of 7 ligands, 3 receptors and 2 co-receptors. Through multiple signaling pathways, VEGF shows capacities of promoting vascular endothelial cell proliferation and angiogenesis, lymphatic endothelial cell growth and lymphatic metastasis, and antiapoptotic cell biology effect. Tumor growth, metastasis and prognosis are closely related with VEGF. Newly-born vessels provide nutrition for tumor growth, as well as providing channel for tumor migration. This review focused on the molecular structure of VEGF and its receptors, signal mechanisms, cytology effects, and its relation with progression and prognosis of oral squamous cell carcinoma （OSCC）.