肝细胞肝癌患者血清胸苷激酶1检测的临床意义

Clinical significance of detection of serum thymidine kinase 1 in patients with hepatocellular carcinoma

目的探讨血清胸苷激酶1(STK1)在诊断肝细胞肝癌(肝癌)中的临床意义。方法采用增强发光免疫点印迹法检测100例肝癌患者(A组)和13例肝血管瘤患者(B组)STK1含量,并以STK1值≤2pmol/L作为参考值对检测结果进行分析。结果 A组STK1值高于B组[(1.94±1.55)pmol/L vs.(0.85±0.44)pmol/L](P<0.05)。A组36例的STK1值>2pmol/L,B组所有病例的STK1值均≤2pmol/L。结论检测STK1有助于肝癌的诊断及肝脏良恶性疾病的鉴别。

Objective To investigate the clinical significance of serum thymidine kinase 1 （STK1） in the diagnosing hepatocellular carcinoma（HCC）. Methods STK1 level was detected by enhanced chemiluminescent dot blot assay in 100 patients with HCC（group A） and 13 cases with liver hemangioma（group B）. Taking STK1 no more than 2 pmol/L as a threshold value, the results were compared between two groups. Results The level of STK1 was significantly higher in group A than that in group B[（1.94±1.55） pmol/L vs. （0. 85±0. 44） pmol/L] （P〈0. 05）. STK1 of 36 cases in group A exceeded 2 pmol/L. STK1 of all cases in group B was no more than 2 pmol/L. Conclusion Detection of STK1 is helpful for diagnosing HCC and differentiating from benign liver diseases.