丝素蛋白应用于椎间盘纤维环组织工程的研究进展

The current development of the silk fibroin applied to annulus fibrosus tissue engineering

[目的]综述国内外有关丝素蛋白应用于椎间盘纤维环组织工程的研究进展,为下一步的实验研究提供理论依据。[方法]广泛查阅近年来国内外有关丝素蛋白的研究成果,尤其是应用于椎间盘纤维环组织工程的相关文献,归纳总结其发展现状和研究进展。[结果]目前丝素蛋白提纯工艺已臻成熟,并且在多个领域得到应用,比如纤维环、软骨、肌腱、韧带组织工程和药物缓释材料等方面。以丝素蛋白为材料制成的支架,结构稳定,力学强度高,还具有良好的生物相容性和可控的生物降解速率,并且能够通过简单的化学修饰来改进各方面的性能。[结论]丝素蛋白作为椎间盘纤维环组织工程支架的理想材料,表现出了良好的发展前景,值得进一步研究和推广。

[ Objective] To review current development of the silk fibroin applied to annulus fibrosus tissue engineering and provide a theoretical basis for the further study. [ Methods ] We extensively reviewed recent research on silk fibroin application, especially about the annulus fibrosus tissue engineering, and summarized the situation and advancement. [ Results] At pres- ent, the extraction technology of silk fibroin had matured. Silk fibroin has been applied in many fields, including annulus fibro- sus, cartilage, tendon, ligament tissue engineering, drug release materials and etc. The silk fibroin scaffold had the characteris- tics of stable structure, high mechanical strength, and also had good biocompatibility and controllable biodegradation rate. Its performance in many aspects can be improved by simple chemical modification. [ Conclusion] Silk fibroin is an ideal material of the annulus fibrosus tissue engineering scaffold. It showed a good development prospect, and deserved further research and extension.